Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer

The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has been linked to the development and initiation of various types of cancer. Recently, epigenetic modifications, particularly N6-methyladenosine (m6A), ha...

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Autores principales: Liu, Jie, Gu, Xinyu, Guan, Zhenjie, Huang, Di, Xing, Huiwu, Zheng, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619263/
https://www.ncbi.nlm.nih.gov/pubmed/37915034
http://dx.doi.org/10.1186/s12967-023-04651-0
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author Liu, Jie
Gu, Xinyu
Guan, Zhenjie
Huang, Di
Xing, Huiwu
Zheng, Lian
author_facet Liu, Jie
Gu, Xinyu
Guan, Zhenjie
Huang, Di
Xing, Huiwu
Zheng, Lian
author_sort Liu, Jie
collection PubMed
description The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has been linked to the development and initiation of various types of cancer. Recently, epigenetic modifications, particularly N6-methyladenosine (m6A), have been recognized as essential contributors to mRNA-related biological processes and translation. The abnormal expression of m6A modification enzymes has been associated with oncogenesis, tumor progression, and drug resistance. Here, we review the role of m6A modification in regulating the PI3K/AKT pathway in cancer and its implications in the development of novel strategies for cancer treatment.
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spelling pubmed-106192632023-11-02 Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer Liu, Jie Gu, Xinyu Guan, Zhenjie Huang, Di Xing, Huiwu Zheng, Lian J Transl Med Review The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has been linked to the development and initiation of various types of cancer. Recently, epigenetic modifications, particularly N6-methyladenosine (m6A), have been recognized as essential contributors to mRNA-related biological processes and translation. The abnormal expression of m6A modification enzymes has been associated with oncogenesis, tumor progression, and drug resistance. Here, we review the role of m6A modification in regulating the PI3K/AKT pathway in cancer and its implications in the development of novel strategies for cancer treatment. BioMed Central 2023-11-01 /pmc/articles/PMC10619263/ /pubmed/37915034 http://dx.doi.org/10.1186/s12967-023-04651-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Jie
Gu, Xinyu
Guan, Zhenjie
Huang, Di
Xing, Huiwu
Zheng, Lian
Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer
title Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer
title_full Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer
title_fullStr Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer
title_full_unstemmed Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer
title_short Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer
title_sort role of m6a modification in regulating the pi3k/akt signaling pathway in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619263/
https://www.ncbi.nlm.nih.gov/pubmed/37915034
http://dx.doi.org/10.1186/s12967-023-04651-0
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