Conventional type 1 dendritic cells (cDC1) in cancer immunity

Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1)...

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Detalles Bibliográficos
Autores principales: Liu, Peng, Zhao, Liwei, Kroemer, Guido, Kepp, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619282/
https://www.ncbi.nlm.nih.gov/pubmed/37907944
http://dx.doi.org/10.1186/s13062-023-00430-5
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author Liu, Peng
Zhao, Liwei
Kroemer, Guido
Kepp, Oliver
author_facet Liu, Peng
Zhao, Liwei
Kroemer, Guido
Kepp, Oliver
author_sort Liu, Peng
collection PubMed
description Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have gained prominence due to their unique ability to cross-present antigens and activate cytotoxic T lymphocytes. This review summarizes the distinctive characteristics of cDC1, their pivotal role in anticancer immunity, and the potential applications of cDC1-based strategies in immunotherapy.
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spelling pubmed-106192822023-11-02 Conventional type 1 dendritic cells (cDC1) in cancer immunity Liu, Peng Zhao, Liwei Kroemer, Guido Kepp, Oliver Biol Direct Review Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have gained prominence due to their unique ability to cross-present antigens and activate cytotoxic T lymphocytes. This review summarizes the distinctive characteristics of cDC1, their pivotal role in anticancer immunity, and the potential applications of cDC1-based strategies in immunotherapy. BioMed Central 2023-11-01 /pmc/articles/PMC10619282/ /pubmed/37907944 http://dx.doi.org/10.1186/s13062-023-00430-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Peng
Zhao, Liwei
Kroemer, Guido
Kepp, Oliver
Conventional type 1 dendritic cells (cDC1) in cancer immunity
title Conventional type 1 dendritic cells (cDC1) in cancer immunity
title_full Conventional type 1 dendritic cells (cDC1) in cancer immunity
title_fullStr Conventional type 1 dendritic cells (cDC1) in cancer immunity
title_full_unstemmed Conventional type 1 dendritic cells (cDC1) in cancer immunity
title_short Conventional type 1 dendritic cells (cDC1) in cancer immunity
title_sort conventional type 1 dendritic cells (cdc1) in cancer immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619282/
https://www.ncbi.nlm.nih.gov/pubmed/37907944
http://dx.doi.org/10.1186/s13062-023-00430-5
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AT keppoliver conventionaltype1dendriticcellscdc1incancerimmunity

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