Structure-informed clustering for population stratification in association studies

BACKGROUND: Identifying variants associated with complex traits is a challenging task in genetic association studies due to linkage disequilibrium (LD) between genetic variants and population stratification, unrelated to the disease risk. Existing methods of population structure correction use princ...

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Detalles Bibliográficos
Autores principales: Bose, Aritra, Burch, Myson, Chowdhury, Agniva, Paschou, Peristera, Drineas, Petros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619291/
https://www.ncbi.nlm.nih.gov/pubmed/37907836
http://dx.doi.org/10.1186/s12859-023-05511-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619291/
https://www.ncbi.nlm.nih.gov/pubmed/37907836
http://dx.doi.org/10.1186/s12859-023-05511-w

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