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Association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study
BACKGROUND: Chronic pain (CP) may increase the risk of acute coronary syndrome (ACS); however, this issue in the older population remains unclear. Therefore, this study was conducted to clarify it. METHODS: We used the Taiwan National Health Insurance Research Database to identify older patients wit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619318/ https://www.ncbi.nlm.nih.gov/pubmed/37907842 http://dx.doi.org/10.1186/s12877-023-04368-1 |
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author | Liu, Yu-Chang Ho, Chung-Han Chen, Yi-Chen Hsu, Chien-Chin Lin, Hung-Jung Wang, Chia-Ti Huang, Chien-Cheng |
author_facet | Liu, Yu-Chang Ho, Chung-Han Chen, Yi-Chen Hsu, Chien-Chin Lin, Hung-Jung Wang, Chia-Ti Huang, Chien-Cheng |
author_sort | Liu, Yu-Chang |
collection | PubMed |
description | BACKGROUND: Chronic pain (CP) may increase the risk of acute coronary syndrome (ACS); however, this issue in the older population remains unclear. Therefore, this study was conducted to clarify it. METHODS: We used the Taiwan National Health Insurance Research Database to identify older patients with CP between 2001 and 2005 as the study cohort. Comparison cohort was the older patients without CP by matching age, sex, and index date at 1:1 ratio with the study cohort in the same period. We also included common underlying comorbidities in the analyses. The risk of ACS was compared between the two cohorts by following up until 2015. RESULTS: A total of 17241 older patients with CP and 17241 older patients without CP were included in this study. In both cohorts, the mean age (± standard deviation) and female percentage were 73.5 (± 5.7) years and 55.4%, respectively. Spinal disorders (31.9%) and osteoarthritis (27.0%) were the most common causes of CP. Older patients with CP had an increased risk for ACS compared to those without CP after adjusting for all underlying comorbidities (adjusted sub-distribution hazard ratio [sHR] 1.18; 95% confidence interval: 1.07–1.30). The increasement of risk of ACS was more when the follow-up period was longer (adjusted sHR of < 3 years: 1.8 vs. <2 years: 1.75 vs. <1 year: 1.55). CONCLUSIONS: CP was associated with an increased risk of ACS in the older population, and the association was more prominent when the follow-up period was longer. Early detection and intervention for CP are suggested in this population. |
format | Online Article Text |
id | pubmed-10619318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106193182023-11-02 Association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study Liu, Yu-Chang Ho, Chung-Han Chen, Yi-Chen Hsu, Chien-Chin Lin, Hung-Jung Wang, Chia-Ti Huang, Chien-Cheng BMC Geriatr Research BACKGROUND: Chronic pain (CP) may increase the risk of acute coronary syndrome (ACS); however, this issue in the older population remains unclear. Therefore, this study was conducted to clarify it. METHODS: We used the Taiwan National Health Insurance Research Database to identify older patients with CP between 2001 and 2005 as the study cohort. Comparison cohort was the older patients without CP by matching age, sex, and index date at 1:1 ratio with the study cohort in the same period. We also included common underlying comorbidities in the analyses. The risk of ACS was compared between the two cohorts by following up until 2015. RESULTS: A total of 17241 older patients with CP and 17241 older patients without CP were included in this study. In both cohorts, the mean age (± standard deviation) and female percentage were 73.5 (± 5.7) years and 55.4%, respectively. Spinal disorders (31.9%) and osteoarthritis (27.0%) were the most common causes of CP. Older patients with CP had an increased risk for ACS compared to those without CP after adjusting for all underlying comorbidities (adjusted sub-distribution hazard ratio [sHR] 1.18; 95% confidence interval: 1.07–1.30). The increasement of risk of ACS was more when the follow-up period was longer (adjusted sHR of < 3 years: 1.8 vs. <2 years: 1.75 vs. <1 year: 1.55). CONCLUSIONS: CP was associated with an increased risk of ACS in the older population, and the association was more prominent when the follow-up period was longer. Early detection and intervention for CP are suggested in this population. BioMed Central 2023-10-31 /pmc/articles/PMC10619318/ /pubmed/37907842 http://dx.doi.org/10.1186/s12877-023-04368-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Liu, Yu-Chang Ho, Chung-Han Chen, Yi-Chen Hsu, Chien-Chin Lin, Hung-Jung Wang, Chia-Ti Huang, Chien-Cheng Association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study |
title | Association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study |
title_full | Association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study |
title_fullStr | Association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study |
title_full_unstemmed | Association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study |
title_short | Association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study |
title_sort | association between chronic pain and acute coronary syndrome in the older population: a nationwide population-based cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619318/ https://www.ncbi.nlm.nih.gov/pubmed/37907842 http://dx.doi.org/10.1186/s12877-023-04368-1 |
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