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Decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia

Cognitive impairment is a major concern in clinical medicine. It is usually evaluated with neuropsychological assessments, which have inherent limitations. To compensate for them, magnetoencephalography has already come into clinical use to evaluate the level of cognitive impairment. It evaluates gl...

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Autores principales: Hoshi, Hideyuki, Kobayashi, Momoko, Hirata, Yoko, Fukasawa, Keisuke, Ichikawa, Sayuri, Shigihara, Yoshihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619364/
https://www.ncbi.nlm.nih.gov/pubmed/37791985
http://dx.doi.org/10.1002/hbm.26507
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author Hoshi, Hideyuki
Kobayashi, Momoko
Hirata, Yoko
Fukasawa, Keisuke
Ichikawa, Sayuri
Shigihara, Yoshihito
author_facet Hoshi, Hideyuki
Kobayashi, Momoko
Hirata, Yoko
Fukasawa, Keisuke
Ichikawa, Sayuri
Shigihara, Yoshihito
author_sort Hoshi, Hideyuki
collection PubMed
description Cognitive impairment is a major concern in clinical medicine. It is usually evaluated with neuropsychological assessments, which have inherent limitations. To compensate for them, magnetoencephalography has already come into clinical use to evaluate the level of cognitive impairment. It evaluates global changes in the frequency of resting‐state brain activity, which are associated with cognitive status. However, it remains unclear what neural mechanism causes the frequency changes. To understand this, it is important to identify cortical regions that mainly contribute to these changes. We retrospectively analysed the clinical records from 310 individuals with cognitive impairment who visited the outpatient department at our hospital. The analysis included resting‐state magnetoencephalography, neuropsychological assessment, and clinical diagnosis data. Regional oscillatory intensities were estimated from the magnetoencephalography data, which were statistically analysed, along with neuropsychological assessment scores, and the severity of cognitive impairment associated with clinical diagnosis. The regional oscillatory intensity covering a wide range of regions and frequencies was significantly associated with neuropsychological assessment scores and differed between healthy individuals and patients with cognitive impairment. However, these associations and differences in all conditions were overlapped by a single change in beta frequency in the left supramarginal gyrus. High frequency oscillatory intensity in the left supramarginal gyrus is associated with cognitive impairment levels among patients who were concerned about dementia. It provides new insights into cognitive status measurements using magnetoencephalography, which is expected to develop as an objective index to be used alongside traditional neuropsychological assessments.
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spelling pubmed-106193642023-11-02 Decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia Hoshi, Hideyuki Kobayashi, Momoko Hirata, Yoko Fukasawa, Keisuke Ichikawa, Sayuri Shigihara, Yoshihito Hum Brain Mapp Research Articles Cognitive impairment is a major concern in clinical medicine. It is usually evaluated with neuropsychological assessments, which have inherent limitations. To compensate for them, magnetoencephalography has already come into clinical use to evaluate the level of cognitive impairment. It evaluates global changes in the frequency of resting‐state brain activity, which are associated with cognitive status. However, it remains unclear what neural mechanism causes the frequency changes. To understand this, it is important to identify cortical regions that mainly contribute to these changes. We retrospectively analysed the clinical records from 310 individuals with cognitive impairment who visited the outpatient department at our hospital. The analysis included resting‐state magnetoencephalography, neuropsychological assessment, and clinical diagnosis data. Regional oscillatory intensities were estimated from the magnetoencephalography data, which were statistically analysed, along with neuropsychological assessment scores, and the severity of cognitive impairment associated with clinical diagnosis. The regional oscillatory intensity covering a wide range of regions and frequencies was significantly associated with neuropsychological assessment scores and differed between healthy individuals and patients with cognitive impairment. However, these associations and differences in all conditions were overlapped by a single change in beta frequency in the left supramarginal gyrus. High frequency oscillatory intensity in the left supramarginal gyrus is associated with cognitive impairment levels among patients who were concerned about dementia. It provides new insights into cognitive status measurements using magnetoencephalography, which is expected to develop as an objective index to be used alongside traditional neuropsychological assessments. John Wiley & Sons, Inc. 2023-10-04 /pmc/articles/PMC10619364/ /pubmed/37791985 http://dx.doi.org/10.1002/hbm.26507 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Hoshi, Hideyuki
Kobayashi, Momoko
Hirata, Yoko
Fukasawa, Keisuke
Ichikawa, Sayuri
Shigihara, Yoshihito
Decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia
title Decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia
title_full Decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia
title_fullStr Decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia
title_full_unstemmed Decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia
title_short Decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia
title_sort decreased beta‐band activity in left supramarginal gyrus reflects cognitive decline: evidence from a large clinical dataset in patients with dementia
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619364/
https://www.ncbi.nlm.nih.gov/pubmed/37791985
http://dx.doi.org/10.1002/hbm.26507
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