Cargando…
Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2
Engineered cytokine–based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. We found that orthotopic murine lung tumors were resistant to systemically deli...
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619440/ https://www.ncbi.nlm.nih.gov/pubmed/37669107 http://dx.doi.org/10.1172/jci.insight.172728 |