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SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A

The histone demethylase JMJD2A/KDM4A facilitates prostate cancer development, yet how JMJD2A function is regulated has remained elusive. Here, we demonstrate that SET7/9-mediated methylation on 6 lysine residues modulated JMJD2A. Joint mutation of these lysine residues suppressed JMJD2A’s ability to...

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Detalles Bibliográficos
Autores principales:	Gu, Ruicai, Kim, Tae-Dong, Song, Hoogeun, Sui, Yuan, Shin, Sook, Oh, Sangphil, Janknecht, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619491/ https://www.ncbi.nlm.nih.gov/pubmed/37870957 http://dx.doi.org/10.1172/jci.insight.164990

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