Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer

Glycolysis is highly enhanced in pancreatic ductal adenocarcinoma (PDAC) cells; thus, glucose restrictions are imposed on nontumor cells in the PDAC tumor microenvironment (TME). However, little is known about how such glucose competition alters metabolism and confers phenotypic changes in stromal c...

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Detalles Bibliográficos
Autores principales: Kitamura, Fumimasa, Semba, Takashi, Yasuda-Yoshihara, Noriko, Yamada, Kosuke, Nishimura, Akiho, Yamasaki, Juntaro, Nagano, Osamu, Yasuda, Tadahito, Yonemura, Atsuko, Tong, Yilin, Wang, Huaitao, Akiyama, Takahiko, Matsumura, Kazuki, Uemura, Norio, Itoyama, Rumi, Bu, Luke, Fu, Lingfeng, Hu, Xichen, Wei, Feng, Mima, Kosuke, Imai, Katsunori, Hayashi, Hiromitsu, Yamashita, Yo-ichi, Miyamoto, Yuji, Baba, Hideo, Ishimoto, Takatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619496/
https://www.ncbi.nlm.nih.gov/pubmed/37733442
http://dx.doi.org/10.1172/jci.insight.163022

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