Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis

Hereditary spherocytosis (HS) is the most common, nonimmune, hereditary, chronic hemolytic anemia after hemoglobinopathies. The genetic defects in membrane function causing HS lead to perturbation of the RBC metabolome, with altered glycolysis. In mice genetically lacking protein 4.2 (4.2(–/–); Epb4...

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Detalles Bibliográficos
Autores principales: Matte, Alessandro, Wilson, Anand B., Gevi, Federica, Federti, Enrica, Recchiuti, Antonio, Ferri, Giulia, Brunati, Anna Maria, Pagano, Mario Angelo, Russo, Roberta, Leboeuf, Christophe, Janin, Anne, Timperio, Anna Maria, Iolascon, Achille, Gremese, Elisa, Dang, Lenny, Mohandas, Narla, Brugnara, Carlo, De Franceschi, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619498/
https://www.ncbi.nlm.nih.gov/pubmed/37676741
http://dx.doi.org/10.1172/jci.insight.172656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619498/
https://www.ncbi.nlm.nih.gov/pubmed/37676741
http://dx.doi.org/10.1172/jci.insight.172656

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