MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival

Host cytosolic sensing of Mycobacterium tuberculosis (M. tuberculosis) RNA by the RIG-I–like receptor (RLR) family perturbs innate immune control within macrophages; however, a distinct role of MDA5, a member of the RLR family, in M. tuberculosis pathogenesis has yet to be fully elucidated. To furth...

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Detalles Bibliográficos
Autores principales: Bullen, C. Korin, Singh, Alok K., Krug, Stefanie, Lun, Shichun, Thakur, Preeti, Srikrishna, Geetha, Bishai, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619499/
https://www.ncbi.nlm.nih.gov/pubmed/37725440
http://dx.doi.org/10.1172/jci.insight.166242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619499/
https://www.ncbi.nlm.nih.gov/pubmed/37725440
http://dx.doi.org/10.1172/jci.insight.166242

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