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MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival
Host cytosolic sensing of Mycobacterium tuberculosis (M. tuberculosis) RNA by the RIG-I–like receptor (RLR) family perturbs innate immune control within macrophages; however, a distinct role of MDA5, a member of the RLR family, in M. tuberculosis pathogenesis has yet to be fully elucidated. To furth...
Autores principales: | Bullen, C. Korin, Singh, Alok K., Krug, Stefanie, Lun, Shichun, Thakur, Preeti, Srikrishna, Geetha, Bishai, William R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619499/ https://www.ncbi.nlm.nih.gov/pubmed/37725440 http://dx.doi.org/10.1172/jci.insight.166242 |
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