Spontaneous Intracranial Hypotension Complicated by a Cerebral Venous Thrombosis Following an mRNA Covid-19 Vaccination: Coincidence vs Cause?

Spontaneous intracranial hypotension (SIH) is a rare cause of persistent headache, particularly among young and middle-aged people. A potentially life-threatening complication of SIH is a cerebral venous thrombosis (CVT). The authors present a case in which a patient presented with SIH complicated by CVT one week after receiving a booster dose of mRNA COVID-19 vaccine. According to our literature review, this is the first such case report. LEARNING POINTS: Spontaneous intracranial hypotension is rarely complicated by cerebral venous thrombosis (CVT). The majority of cerebral venous thrombosis cases post-COVID-19 vaccination occurred in patients administered with adenoviral vaccines. CVT following administration of mRNA COVID-19 vaccines is rare. Clinicians should consider COVID-19 vaccine-induced CVT in recently vaccinated patients; MRI plays an important role in accurate diagnosis.