Cargando…
Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C
OBJECTIVE: To identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic. METHODS: Across 25 U.S. Overcoming COVID-19 Network hospitals, we cond...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619659/ https://www.ncbi.nlm.nih.gov/pubmed/37920792 http://dx.doi.org/10.3389/fped.2023.1260372 |
_version_ | 1785130033894916096 |
---|---|
author | Maddux, Aline B. Young, Cameron C. Kucukak, Suden Zambrano, Laura D. Newhams, Margaret M. Rollins, Caitlin K. Halasa, Natasha B. Gertz, Shira J. Mack, Elizabeth H. Schwartz, Stephanie Kong, Michele Loftis, Laura L. Irby, Katherine Rowan, Courtney M. Tarquinio, Keiko M. Zinter, Matt S. Crandall, Hillary Cvijanovich, Natalie Z. Schuster, Jennifer E. Fitzgerald, Julie C. Staat, Mary A. Hobbs, Charlotte V. Nofziger, Ryan A. Shein, Steven Flori, Heidi Cullimore, Melissa L. Chatani, Brandon M. Levy, Emily R. Typpo, Katri V. Hume, Janet R. Campbell, Angela P. Randolph, Adrienne G. |
author_facet | Maddux, Aline B. Young, Cameron C. Kucukak, Suden Zambrano, Laura D. Newhams, Margaret M. Rollins, Caitlin K. Halasa, Natasha B. Gertz, Shira J. Mack, Elizabeth H. Schwartz, Stephanie Kong, Michele Loftis, Laura L. Irby, Katherine Rowan, Courtney M. Tarquinio, Keiko M. Zinter, Matt S. Crandall, Hillary Cvijanovich, Natalie Z. Schuster, Jennifer E. Fitzgerald, Julie C. Staat, Mary A. Hobbs, Charlotte V. Nofziger, Ryan A. Shein, Steven Flori, Heidi Cullimore, Melissa L. Chatani, Brandon M. Levy, Emily R. Typpo, Katri V. Hume, Janet R. Campbell, Angela P. Randolph, Adrienne G. |
author_sort | Maddux, Aline B. |
collection | PubMed |
description | OBJECTIVE: To identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic. METHODS: Across 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI). RESULTS: Of 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments. DISCUSSION: Among patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. |
format | Online Article Text |
id | pubmed-10619659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106196592023-11-02 Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C Maddux, Aline B. Young, Cameron C. Kucukak, Suden Zambrano, Laura D. Newhams, Margaret M. Rollins, Caitlin K. Halasa, Natasha B. Gertz, Shira J. Mack, Elizabeth H. Schwartz, Stephanie Kong, Michele Loftis, Laura L. Irby, Katherine Rowan, Courtney M. Tarquinio, Keiko M. Zinter, Matt S. Crandall, Hillary Cvijanovich, Natalie Z. Schuster, Jennifer E. Fitzgerald, Julie C. Staat, Mary A. Hobbs, Charlotte V. Nofziger, Ryan A. Shein, Steven Flori, Heidi Cullimore, Melissa L. Chatani, Brandon M. Levy, Emily R. Typpo, Katri V. Hume, Janet R. Campbell, Angela P. Randolph, Adrienne G. Front Pediatr Pediatrics OBJECTIVE: To identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic. METHODS: Across 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI). RESULTS: Of 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments. DISCUSSION: Among patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10619659/ /pubmed/37920792 http://dx.doi.org/10.3389/fped.2023.1260372 Text en © 2023 Maddux, Young, Kucukak, Zambrano, Newhams, Rollins, Halasa, Gertz, Mack, Schwartz, Kong, Loftis, Irby, Rowan, Tarquinio, Zinter, Crandall, Cvijanovich, Schuster, Fitzgerald, Staat, Hobbs, Nofziger, Shein, Flori, Cullimore, Chatani, Levy, Typpo, Hume, Campbell, Randolph and the Overcoming COVID-19 Investigators. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Maddux, Aline B. Young, Cameron C. Kucukak, Suden Zambrano, Laura D. Newhams, Margaret M. Rollins, Caitlin K. Halasa, Natasha B. Gertz, Shira J. Mack, Elizabeth H. Schwartz, Stephanie Kong, Michele Loftis, Laura L. Irby, Katherine Rowan, Courtney M. Tarquinio, Keiko M. Zinter, Matt S. Crandall, Hillary Cvijanovich, Natalie Z. Schuster, Jennifer E. Fitzgerald, Julie C. Staat, Mary A. Hobbs, Charlotte V. Nofziger, Ryan A. Shein, Steven Flori, Heidi Cullimore, Melissa L. Chatani, Brandon M. Levy, Emily R. Typpo, Katri V. Hume, Janet R. Campbell, Angela P. Randolph, Adrienne G. Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
title | Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
title_full | Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
title_fullStr | Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
title_full_unstemmed | Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
title_short | Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
title_sort | risk factors for health impairments in children after hospitalization for acute covid-19 or mis-c |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619659/ https://www.ncbi.nlm.nih.gov/pubmed/37920792 http://dx.doi.org/10.3389/fped.2023.1260372 |
work_keys_str_mv | AT madduxalineb riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT youngcameronc riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT kucukaksuden riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT zambranolaurad riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT newhamsmargaretm riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT rollinscaitlink riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT halasanatashab riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT gertzshiraj riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT mackelizabethh riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT schwartzstephanie riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT kongmichele riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT loftislaural riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT irbykatherine riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT rowancourtneym riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT tarquiniokeikom riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT zintermatts riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT crandallhillary riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT cvijanovichnataliez riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT schusterjennifere riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT fitzgeraldjuliec riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT staatmarya riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT hobbscharlottev riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT nofzigerryana riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT sheinsteven riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT floriheidi riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT cullimoremelissal riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT chatanibrandonm riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT levyemilyr riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT typpokatriv riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT humejanetr riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT campbellangelap riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT randolphadrienneg riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc AT riskfactorsforhealthimpairmentsinchildrenafterhospitalizationforacutecovid19ormisc |