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Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases

Naturally occurring flavonoids have long been utilized as essential templates for the development of novel drugs and as critical ingredients for functional foods. Astragalin (AG) is a natural flavonoid that can be isolated from a variety of familiar edible plants, such as the seeds of green tea, Mor...

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Autores principales: Chen, Junren, Zhong, Kexin, Qin, Siqi, Jing, Yiqi, Liu, Shengmeng, Li, Dan, Peng, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619670/
https://www.ncbi.nlm.nih.gov/pubmed/37920216
http://dx.doi.org/10.3389/fphar.2023.1265960
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author Chen, Junren
Zhong, Kexin
Qin, Siqi
Jing, Yiqi
Liu, Shengmeng
Li, Dan
Peng, Cheng
author_facet Chen, Junren
Zhong, Kexin
Qin, Siqi
Jing, Yiqi
Liu, Shengmeng
Li, Dan
Peng, Cheng
author_sort Chen, Junren
collection PubMed
description Naturally occurring flavonoids have long been utilized as essential templates for the development of novel drugs and as critical ingredients for functional foods. Astragalin (AG) is a natural flavonoid that can be isolated from a variety of familiar edible plants, such as the seeds of green tea, Morus alba L., and Cuscuta chinensis. It is noteworthy that AG has a wide range of pharmacological activities and possesses therapeutic effects against a variety of diseases, covering cancers, osteoarthritis, osteoporosis, ulcerative colitis, mastitis, obesity, diabetes mellitus, diabetic complications, ischemia/reperfusion injury, neuropathy, respiratory diseases, and reproductive system diseases. This article reviewed the natural source and pharmacokinetics of AG and systematically summarized the pharmacological activities and potential mechanisms of AG in treating diverse diseases in order to promote the development of AG as a functional food, in doing so providing references for its clinical application in disease therapy.
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spelling pubmed-106196702023-11-02 Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases Chen, Junren Zhong, Kexin Qin, Siqi Jing, Yiqi Liu, Shengmeng Li, Dan Peng, Cheng Front Pharmacol Pharmacology Naturally occurring flavonoids have long been utilized as essential templates for the development of novel drugs and as critical ingredients for functional foods. Astragalin (AG) is a natural flavonoid that can be isolated from a variety of familiar edible plants, such as the seeds of green tea, Morus alba L., and Cuscuta chinensis. It is noteworthy that AG has a wide range of pharmacological activities and possesses therapeutic effects against a variety of diseases, covering cancers, osteoarthritis, osteoporosis, ulcerative colitis, mastitis, obesity, diabetes mellitus, diabetic complications, ischemia/reperfusion injury, neuropathy, respiratory diseases, and reproductive system diseases. This article reviewed the natural source and pharmacokinetics of AG and systematically summarized the pharmacological activities and potential mechanisms of AG in treating diverse diseases in order to promote the development of AG as a functional food, in doing so providing references for its clinical application in disease therapy. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10619670/ /pubmed/37920216 http://dx.doi.org/10.3389/fphar.2023.1265960 Text en Copyright © 2023 Chen, Zhong, Qin, Jing, Liu, Li and Peng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Junren
Zhong, Kexin
Qin, Siqi
Jing, Yiqi
Liu, Shengmeng
Li, Dan
Peng, Cheng
Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases
title Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases
title_full Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases
title_fullStr Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases
title_full_unstemmed Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases
title_short Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases
title_sort astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619670/
https://www.ncbi.nlm.nih.gov/pubmed/37920216
http://dx.doi.org/10.3389/fphar.2023.1265960
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