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The journey of stage III and IV non-small cell lung cancer patients in the Brazilian private healthcare system: a retrospective study
Non-small cell lung cancer (NSCLC) is still diagnosed at late stages in Brazil. The availability of newer treatment options has changed patient management, however, few real-world data have been published since then. This is a population-based retrospective cohort study that aims to evaluate the cha...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619689/ https://www.ncbi.nlm.nih.gov/pubmed/37920156 http://dx.doi.org/10.3389/fonc.2023.1257003 |
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author | Cerqueira, Erica R. Batista, Paula M. Almeida, Milena F. Rego, Maria A. C. Ribeiro-Pereira, Ana C. P. Alencar, Fernando Fernandes, Roberta A. Calabrich, Aknar F. C. Schvartsman, Gustavo |
author_facet | Cerqueira, Erica R. Batista, Paula M. Almeida, Milena F. Rego, Maria A. C. Ribeiro-Pereira, Ana C. P. Alencar, Fernando Fernandes, Roberta A. Calabrich, Aknar F. C. Schvartsman, Gustavo |
author_sort | Cerqueira, Erica R. |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is still diagnosed at late stages in Brazil. The availability of newer treatment options has changed patient management, however, few real-world data have been published since then. This is a population-based retrospective cohort study that aims to evaluate the characteristics of stage III/IV NSCLC patients and their journey in the Brazilian private healthcare system. Patients aged ≥18 years, residing in Brazil who had their first medical appointment between 2016 and 2018 were included in the study. The sociodemographic and clinical characteristics of the patients and time intervals of interest were described. A total of 10,394 patients were analyzed. The majority of the patients were male (58.5%) with a median age of 64.0 (IQR = 58.0 – 71.0) years. In relation to characteristics of the disease, most of the tumors were characterized as adenocarcinomas (52.3%) and diagnosed at stage IV (72.2%). Most patients arrived at the hospital with an established NSCLC diagnosis, while 45.7% were diagnosed at the first medical appointment in the hospital or later. For patients who were diagnosed at the first medical appointment or later, a median interval of 15.0 (IQR = 6.0 – 33.0) days was observed between the first medical appointment and the diagnosis. The first treatment was given after a median of 25.0 (IQR = 6.0 – 49.0) days after diagnosis for patients without a prior diagnosis, and 57.0 (IQR: 33.0 – 98.0) days for patients with a prior diagnosis. The most common treatments were chemotherapy alone (33.8%), chemotherapy combined with radiotherapy (21.5%), radiotherapy alone (13.1%), adjuvant or neoadjuvant treatment (9.3%), surgery (3.3%), and immunotherapy (0.7%; alone or combined). At the end of follow-up (September, 2020), 52.3% of the patients had died. Despite having more treatment options in the private sector, data show that there is a need to improve access to technologies. |
format | Online Article Text |
id | pubmed-10619689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106196892023-11-02 The journey of stage III and IV non-small cell lung cancer patients in the Brazilian private healthcare system: a retrospective study Cerqueira, Erica R. Batista, Paula M. Almeida, Milena F. Rego, Maria A. C. Ribeiro-Pereira, Ana C. P. Alencar, Fernando Fernandes, Roberta A. Calabrich, Aknar F. C. Schvartsman, Gustavo Front Oncol Oncology Non-small cell lung cancer (NSCLC) is still diagnosed at late stages in Brazil. The availability of newer treatment options has changed patient management, however, few real-world data have been published since then. This is a population-based retrospective cohort study that aims to evaluate the characteristics of stage III/IV NSCLC patients and their journey in the Brazilian private healthcare system. Patients aged ≥18 years, residing in Brazil who had their first medical appointment between 2016 and 2018 were included in the study. The sociodemographic and clinical characteristics of the patients and time intervals of interest were described. A total of 10,394 patients were analyzed. The majority of the patients were male (58.5%) with a median age of 64.0 (IQR = 58.0 – 71.0) years. In relation to characteristics of the disease, most of the tumors were characterized as adenocarcinomas (52.3%) and diagnosed at stage IV (72.2%). Most patients arrived at the hospital with an established NSCLC diagnosis, while 45.7% were diagnosed at the first medical appointment in the hospital or later. For patients who were diagnosed at the first medical appointment or later, a median interval of 15.0 (IQR = 6.0 – 33.0) days was observed between the first medical appointment and the diagnosis. The first treatment was given after a median of 25.0 (IQR = 6.0 – 49.0) days after diagnosis for patients without a prior diagnosis, and 57.0 (IQR: 33.0 – 98.0) days for patients with a prior diagnosis. The most common treatments were chemotherapy alone (33.8%), chemotherapy combined with radiotherapy (21.5%), radiotherapy alone (13.1%), adjuvant or neoadjuvant treatment (9.3%), surgery (3.3%), and immunotherapy (0.7%; alone or combined). At the end of follow-up (September, 2020), 52.3% of the patients had died. Despite having more treatment options in the private sector, data show that there is a need to improve access to technologies. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10619689/ /pubmed/37920156 http://dx.doi.org/10.3389/fonc.2023.1257003 Text en Copyright © 2023 Cerqueira, Batista, Almeida, Rego, Ribeiro-Pereira, Alencar, Fernandes, Calabrich and Schvartsman https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Cerqueira, Erica R. Batista, Paula M. Almeida, Milena F. Rego, Maria A. C. Ribeiro-Pereira, Ana C. P. Alencar, Fernando Fernandes, Roberta A. Calabrich, Aknar F. C. Schvartsman, Gustavo The journey of stage III and IV non-small cell lung cancer patients in the Brazilian private healthcare system: a retrospective study |
title | The journey of stage III and IV non-small cell lung cancer patients in the Brazilian private healthcare system: a retrospective study |
title_full | The journey of stage III and IV non-small cell lung cancer patients in the Brazilian private healthcare system: a retrospective study |
title_fullStr | The journey of stage III and IV non-small cell lung cancer patients in the Brazilian private healthcare system: a retrospective study |
title_full_unstemmed | The journey of stage III and IV non-small cell lung cancer patients in the Brazilian private healthcare system: a retrospective study |
title_short | The journey of stage III and IV non-small cell lung cancer patients in the Brazilian private healthcare system: a retrospective study |
title_sort | journey of stage iii and iv non-small cell lung cancer patients in the brazilian private healthcare system: a retrospective study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619689/ https://www.ncbi.nlm.nih.gov/pubmed/37920156 http://dx.doi.org/10.3389/fonc.2023.1257003 |
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