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Sestrin2 in diabetes and diabetic complications
Diabetes is a global health problem which is accompanied with multi-systemic complications. It is of great significance to elucidate the pathogenesis and to identify novel therapies of diabetes and diabetic complications. Sestrin2, a stress-inducible protein, is primarily involved in cellular respon...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619741/ https://www.ncbi.nlm.nih.gov/pubmed/37920252 http://dx.doi.org/10.3389/fendo.2023.1274686 |
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author | Zhang, Xiaodan Luo, Zirui Li, Jiahong Lin, Yaxuan Li, Yu Li, Wangen |
author_facet | Zhang, Xiaodan Luo, Zirui Li, Jiahong Lin, Yaxuan Li, Yu Li, Wangen |
author_sort | Zhang, Xiaodan |
collection | PubMed |
description | Diabetes is a global health problem which is accompanied with multi-systemic complications. It is of great significance to elucidate the pathogenesis and to identify novel therapies of diabetes and diabetic complications. Sestrin2, a stress-inducible protein, is primarily involved in cellular responses to various stresses. It plays critical roles in regulating a series of cellular events, such as oxidative stress, mitochondrial function and endoplasmic reticulum stress. Researches investigating the correlations between Sestrin2, diabetes and diabetic complications are increasing in recent years. This review incorporates recent findings, demonstrates the diverse functions and regulating mechanisms of Sestrin2, and discusses the potential roles of Sestrin2 in the pathogenesis of diabetes and diabetic complications, hoping to highlight a promising therapeutic direction. |
format | Online Article Text |
id | pubmed-10619741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106197412023-11-02 Sestrin2 in diabetes and diabetic complications Zhang, Xiaodan Luo, Zirui Li, Jiahong Lin, Yaxuan Li, Yu Li, Wangen Front Endocrinol (Lausanne) Endocrinology Diabetes is a global health problem which is accompanied with multi-systemic complications. It is of great significance to elucidate the pathogenesis and to identify novel therapies of diabetes and diabetic complications. Sestrin2, a stress-inducible protein, is primarily involved in cellular responses to various stresses. It plays critical roles in regulating a series of cellular events, such as oxidative stress, mitochondrial function and endoplasmic reticulum stress. Researches investigating the correlations between Sestrin2, diabetes and diabetic complications are increasing in recent years. This review incorporates recent findings, demonstrates the diverse functions and regulating mechanisms of Sestrin2, and discusses the potential roles of Sestrin2 in the pathogenesis of diabetes and diabetic complications, hoping to highlight a promising therapeutic direction. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10619741/ /pubmed/37920252 http://dx.doi.org/10.3389/fendo.2023.1274686 Text en Copyright © 2023 Zhang, Luo, Li, Lin, Li and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Zhang, Xiaodan Luo, Zirui Li, Jiahong Lin, Yaxuan Li, Yu Li, Wangen Sestrin2 in diabetes and diabetic complications |
title | Sestrin2 in diabetes and diabetic complications |
title_full | Sestrin2 in diabetes and diabetic complications |
title_fullStr | Sestrin2 in diabetes and diabetic complications |
title_full_unstemmed | Sestrin2 in diabetes and diabetic complications |
title_short | Sestrin2 in diabetes and diabetic complications |
title_sort | sestrin2 in diabetes and diabetic complications |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619741/ https://www.ncbi.nlm.nih.gov/pubmed/37920252 http://dx.doi.org/10.3389/fendo.2023.1274686 |
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