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Examination of betahistine bioavailability in combination with the monoamine oxidase B inhibitor, selegiline, in humans—a non-randomized, single-sequence, two-period titration, open label single-center phase 1 study (PK-BeST)
BACKGROUND: Betahistine was registered in Europe in the 1970s and approved in more than 80 countries as a first-line treatment for Menière's disease. It has been administered to more than 150 million patients. However, according to a Cochrane systematic review of betahistine and recent meta-ana...
Autores principales: | Strupp, Michael, Churchill, Grant C., Naumann, Ivonne, Mansmann, Ulrich, Al Tawil, Amani, Golentsova, Anastasia, Goldschagg, Nicolina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619746/ https://www.ncbi.nlm.nih.gov/pubmed/37920833 http://dx.doi.org/10.3389/fneur.2023.1271640 |
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