The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection

Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood. Here, we report that the purinergic receptor P2X7 and NLRP3 infla...

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Detalles Bibliográficos
Autores principales: Lécuyer, Déborah, Nardacci, Roberta, Tannous, Désirée, Gutierrez-Mateyron, Emie, Deva Nathan, Aurélia, Subra, Frédéric, Di Primio, Cristina, Quaranta, Paola, Petit, Vanessa, Richetta, Clémence, Mostefa-Kara, Ali, Del Nonno, Franca, Falasca, Laura, Marlin, Romain, Maisonnasse, Pauline, Delahousse, Julia, Pascaud, Juliette, Deprez, Eric, Naigeon, Marie, Chaput, Nathalie, Paci, Angelo, Saada, Véronique, Ghez, David, Mariette, Xavier, Costa, Mario, Pistello, Mauro, Allouch, Awatef, Delelis, Olivier, Piacentini, Mauro, Le Grand, Roger, Perfettini, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619763/
https://www.ncbi.nlm.nih.gov/pubmed/37920468
http://dx.doi.org/10.3389/fimmu.2023.1270081

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