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Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics

AIMS: Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated “ex-thalassaemics”. Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart failure-related morbidity and mortality is unknown....

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Autores principales: Paul, Amal, Kulkarni, Uday, Yadav, Bijesh, Aboobacker, Fouzia N., Devasia, Anup J., Korula, Anu, Abraham, Aby, George, Biju, George, Paul V., Srivastava, Alok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619803/
https://www.ncbi.nlm.nih.gov/pubmed/37910595
http://dx.doi.org/10.1371/journal.pone.0293452
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author Paul, Amal
Kulkarni, Uday
Yadav, Bijesh
Aboobacker, Fouzia N.
Devasia, Anup J.
Korula, Anu
Abraham, Aby
George, Biju
George, Paul V.
Srivastava, Alok
author_facet Paul, Amal
Kulkarni, Uday
Yadav, Bijesh
Aboobacker, Fouzia N.
Devasia, Anup J.
Korula, Anu
Abraham, Aby
George, Biju
George, Paul V.
Srivastava, Alok
author_sort Paul, Amal
collection PubMed
description AIMS: Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated “ex-thalassaemics”. Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart failure-related morbidity and mortality is unknown. The aim of this study was to assess the prevalence and predictors of subclinical left ventricular (LV) dysfunction in an apparently normal ex-thalassaemic population. METHODS: We conducted a single centre cross-sectional study among 62 ex-thalassaemic patients, who had undergone HSCT for β-thalassaemia major at our centre. The primary outcome variable was LV systolic dysfunction, as assessed by 1) LV global longitudinal strain (GLS) derived by 2D speckle tracking echocardiography and 2) LV ejection fraction (EF) derived by 2D Simpsons Biplane method. RESULTS: Among the 62 patients included in the study, 7 [11.3%] were found to have LV systolic dysfunction, all of which were subclinical. Of these, 4 [6.5%] had abnormal GLS and LVEF, 2 [3.2%] had abnormal GLS with normal LVEF, and 1 [1.6%] had abnormal LVEF with low normal mean GLS. There were no statistically significant predictors of LV dysfunction in this cohort. CONCLUSION: There was a high prevalence of subclinical myocardial dysfunction in the ex-thalassaemic population reiterating the need for close follow up of these patients. 2D Speckle tracking echocardiography-derived LV global longitudinal strain is an effective tool in detecting subclinical myocardial dysfunction in this cohort.
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spelling pubmed-106198032023-11-02 Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics Paul, Amal Kulkarni, Uday Yadav, Bijesh Aboobacker, Fouzia N. Devasia, Anup J. Korula, Anu Abraham, Aby George, Biju George, Paul V. Srivastava, Alok PLoS One Research Article AIMS: Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated “ex-thalassaemics”. Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart failure-related morbidity and mortality is unknown. The aim of this study was to assess the prevalence and predictors of subclinical left ventricular (LV) dysfunction in an apparently normal ex-thalassaemic population. METHODS: We conducted a single centre cross-sectional study among 62 ex-thalassaemic patients, who had undergone HSCT for β-thalassaemia major at our centre. The primary outcome variable was LV systolic dysfunction, as assessed by 1) LV global longitudinal strain (GLS) derived by 2D speckle tracking echocardiography and 2) LV ejection fraction (EF) derived by 2D Simpsons Biplane method. RESULTS: Among the 62 patients included in the study, 7 [11.3%] were found to have LV systolic dysfunction, all of which were subclinical. Of these, 4 [6.5%] had abnormal GLS and LVEF, 2 [3.2%] had abnormal GLS with normal LVEF, and 1 [1.6%] had abnormal LVEF with low normal mean GLS. There were no statistically significant predictors of LV dysfunction in this cohort. CONCLUSION: There was a high prevalence of subclinical myocardial dysfunction in the ex-thalassaemic population reiterating the need for close follow up of these patients. 2D Speckle tracking echocardiography-derived LV global longitudinal strain is an effective tool in detecting subclinical myocardial dysfunction in this cohort. Public Library of Science 2023-11-01 /pmc/articles/PMC10619803/ /pubmed/37910595 http://dx.doi.org/10.1371/journal.pone.0293452 Text en © 2023 Paul et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Paul, Amal
Kulkarni, Uday
Yadav, Bijesh
Aboobacker, Fouzia N.
Devasia, Anup J.
Korula, Anu
Abraham, Aby
George, Biju
George, Paul V.
Srivastava, Alok
Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics
title Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics
title_full Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics
title_fullStr Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics
title_full_unstemmed Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics
title_short Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics
title_sort speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619803/
https://www.ncbi.nlm.nih.gov/pubmed/37910595
http://dx.doi.org/10.1371/journal.pone.0293452
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