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Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic
Healthcare workers (HCWs) are at high to very high risk for SARS-CoV-2 infection. The persistence of this pandemic worldwide has instigated the need for an investigation of the level of prevention through immunization and vaccination against SARS-CoV-2 among HCWs. The objective of our study was to e...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619860/ https://www.ncbi.nlm.nih.gov/pubmed/37910467 http://dx.doi.org/10.1371/journal.pgph.0001497 |
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author | Manirakiza, Alexandre Malaka, Christian Mossoro-Kpinde, Hermione Dahlia Yambiyo, Brice Martial Mossoro-Kpinde, Christian Diamant Fandema, Emmanuel Niamathe Yakola, Christelle Doyama-Woza, Rodrigue Kangale-Wando, Ida Maxime Kosh Komba, Jess Elliot Nzapali Guiagassomon, Sandra Manuella Bénedicte Namsenei-Dankpea, Lydie Joella-Venus de la Grace Coti-Reckoundji, Cathy Sandra Gomelle Bouhouda, Modeste Gody, Jean-Chrisostome Grésenguet, Gérard Vernet, Guy Vernet, Marie Astrid Nakoune, Emmanuel |
author_facet | Manirakiza, Alexandre Malaka, Christian Mossoro-Kpinde, Hermione Dahlia Yambiyo, Brice Martial Mossoro-Kpinde, Christian Diamant Fandema, Emmanuel Niamathe Yakola, Christelle Doyama-Woza, Rodrigue Kangale-Wando, Ida Maxime Kosh Komba, Jess Elliot Nzapali Guiagassomon, Sandra Manuella Bénedicte Namsenei-Dankpea, Lydie Joella-Venus de la Grace Coti-Reckoundji, Cathy Sandra Gomelle Bouhouda, Modeste Gody, Jean-Chrisostome Grésenguet, Gérard Vernet, Guy Vernet, Marie Astrid Nakoune, Emmanuel |
author_sort | Manirakiza, Alexandre |
collection | PubMed |
description | Healthcare workers (HCWs) are at high to very high risk for SARS-CoV-2 infection. The persistence of this pandemic worldwide has instigated the need for an investigation of the level of prevention through immunization and vaccination against SARS-CoV-2 among HCWs. The objective of our study was to evaluate any changes in anti-COVID-19 serological status before and after the vaccination campaign of health personnel in the Central African Republic. We carried out a repeated cross-sectional serological study on HCWs at the university hospital centers of Bangui. Blood samples were collected and tested for anti-SARS-CoV-2 IgM and IgG using the ELISA technique on blood samples. A total of 179 and 141 HCWs were included in the first and second surveys, respectively. Of these staff, 31.8% of HCWs were positive for anti-SARS-CoV-2 IgG in the first survey, whereas 95.7% were positive for anti-SARS-CoV-2 IgG in the second survey. However, the proportion of HCWs positive for SARS-CoV-2 IgM antibodies was low (9.7% in the first survey and 3.6% in the second survey). These findings showed a sharp increase in seroprevalence over a one-year period. This increase is primarily due to the synergistic effect of the infection and the implementation of vaccines against COVID-19. Further studies to assess the persistence of anti-SARS-CoV-2 antibodies are needed. |
format | Online Article Text |
id | pubmed-10619860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106198602023-11-02 Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic Manirakiza, Alexandre Malaka, Christian Mossoro-Kpinde, Hermione Dahlia Yambiyo, Brice Martial Mossoro-Kpinde, Christian Diamant Fandema, Emmanuel Niamathe Yakola, Christelle Doyama-Woza, Rodrigue Kangale-Wando, Ida Maxime Kosh Komba, Jess Elliot Nzapali Guiagassomon, Sandra Manuella Bénedicte Namsenei-Dankpea, Lydie Joella-Venus de la Grace Coti-Reckoundji, Cathy Sandra Gomelle Bouhouda, Modeste Gody, Jean-Chrisostome Grésenguet, Gérard Vernet, Guy Vernet, Marie Astrid Nakoune, Emmanuel PLOS Glob Public Health Research Article Healthcare workers (HCWs) are at high to very high risk for SARS-CoV-2 infection. The persistence of this pandemic worldwide has instigated the need for an investigation of the level of prevention through immunization and vaccination against SARS-CoV-2 among HCWs. The objective of our study was to evaluate any changes in anti-COVID-19 serological status before and after the vaccination campaign of health personnel in the Central African Republic. We carried out a repeated cross-sectional serological study on HCWs at the university hospital centers of Bangui. Blood samples were collected and tested for anti-SARS-CoV-2 IgM and IgG using the ELISA technique on blood samples. A total of 179 and 141 HCWs were included in the first and second surveys, respectively. Of these staff, 31.8% of HCWs were positive for anti-SARS-CoV-2 IgG in the first survey, whereas 95.7% were positive for anti-SARS-CoV-2 IgG in the second survey. However, the proportion of HCWs positive for SARS-CoV-2 IgM antibodies was low (9.7% in the first survey and 3.6% in the second survey). These findings showed a sharp increase in seroprevalence over a one-year period. This increase is primarily due to the synergistic effect of the infection and the implementation of vaccines against COVID-19. Further studies to assess the persistence of anti-SARS-CoV-2 antibodies are needed. Public Library of Science 2023-11-01 /pmc/articles/PMC10619860/ /pubmed/37910467 http://dx.doi.org/10.1371/journal.pgph.0001497 Text en © 2023 Manirakiza et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Manirakiza, Alexandre Malaka, Christian Mossoro-Kpinde, Hermione Dahlia Yambiyo, Brice Martial Mossoro-Kpinde, Christian Diamant Fandema, Emmanuel Niamathe Yakola, Christelle Doyama-Woza, Rodrigue Kangale-Wando, Ida Maxime Kosh Komba, Jess Elliot Nzapali Guiagassomon, Sandra Manuella Bénedicte Namsenei-Dankpea, Lydie Joella-Venus de la Grace Coti-Reckoundji, Cathy Sandra Gomelle Bouhouda, Modeste Gody, Jean-Chrisostome Grésenguet, Gérard Vernet, Guy Vernet, Marie Astrid Nakoune, Emmanuel Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic |
title | Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic |
title_full | Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic |
title_fullStr | Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic |
title_full_unstemmed | Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic |
title_short | Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic |
title_sort | seroprevalence of anti-sars-cov-2 antibodies before and after implementation of anti-covid-19 vaccination among hospital staff in bangui, central african republic |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619860/ https://www.ncbi.nlm.nih.gov/pubmed/37910467 http://dx.doi.org/10.1371/journal.pgph.0001497 |
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