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Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic

Healthcare workers (HCWs) are at high to very high risk for SARS-CoV-2 infection. The persistence of this pandemic worldwide has instigated the need for an investigation of the level of prevention through immunization and vaccination against SARS-CoV-2 among HCWs. The objective of our study was to e...

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Autores principales: Manirakiza, Alexandre, Malaka, Christian, Mossoro-Kpinde, Hermione Dahlia, Yambiyo, Brice Martial, Mossoro-Kpinde, Christian Diamant, Fandema, Emmanuel, Niamathe Yakola, Christelle, Doyama-Woza, Rodrigue, Kangale-Wando, Ida Maxime, Kosh Komba, Jess Elliot, Nzapali Guiagassomon, Sandra Manuella Bénedicte, Namsenei-Dankpea, Lydie Joella-Venus de la Grace, Coti-Reckoundji, Cathy Sandra Gomelle, Bouhouda, Modeste, Gody, Jean-Chrisostome, Grésenguet, Gérard, Vernet, Guy, Vernet, Marie Astrid, Nakoune, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619860/
https://www.ncbi.nlm.nih.gov/pubmed/37910467
http://dx.doi.org/10.1371/journal.pgph.0001497
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author Manirakiza, Alexandre
Malaka, Christian
Mossoro-Kpinde, Hermione Dahlia
Yambiyo, Brice Martial
Mossoro-Kpinde, Christian Diamant
Fandema, Emmanuel
Niamathe Yakola, Christelle
Doyama-Woza, Rodrigue
Kangale-Wando, Ida Maxime
Kosh Komba, Jess Elliot
Nzapali Guiagassomon, Sandra Manuella Bénedicte
Namsenei-Dankpea, Lydie Joella-Venus de la Grace
Coti-Reckoundji, Cathy Sandra Gomelle
Bouhouda, Modeste
Gody, Jean-Chrisostome
Grésenguet, Gérard
Vernet, Guy
Vernet, Marie Astrid
Nakoune, Emmanuel
author_facet Manirakiza, Alexandre
Malaka, Christian
Mossoro-Kpinde, Hermione Dahlia
Yambiyo, Brice Martial
Mossoro-Kpinde, Christian Diamant
Fandema, Emmanuel
Niamathe Yakola, Christelle
Doyama-Woza, Rodrigue
Kangale-Wando, Ida Maxime
Kosh Komba, Jess Elliot
Nzapali Guiagassomon, Sandra Manuella Bénedicte
Namsenei-Dankpea, Lydie Joella-Venus de la Grace
Coti-Reckoundji, Cathy Sandra Gomelle
Bouhouda, Modeste
Gody, Jean-Chrisostome
Grésenguet, Gérard
Vernet, Guy
Vernet, Marie Astrid
Nakoune, Emmanuel
author_sort Manirakiza, Alexandre
collection PubMed
description Healthcare workers (HCWs) are at high to very high risk for SARS-CoV-2 infection. The persistence of this pandemic worldwide has instigated the need for an investigation of the level of prevention through immunization and vaccination against SARS-CoV-2 among HCWs. The objective of our study was to evaluate any changes in anti-COVID-19 serological status before and after the vaccination campaign of health personnel in the Central African Republic. We carried out a repeated cross-sectional serological study on HCWs at the university hospital centers of Bangui. Blood samples were collected and tested for anti-SARS-CoV-2 IgM and IgG using the ELISA technique on blood samples. A total of 179 and 141 HCWs were included in the first and second surveys, respectively. Of these staff, 31.8% of HCWs were positive for anti-SARS-CoV-2 IgG in the first survey, whereas 95.7% were positive for anti-SARS-CoV-2 IgG in the second survey. However, the proportion of HCWs positive for SARS-CoV-2 IgM antibodies was low (9.7% in the first survey and 3.6% in the second survey). These findings showed a sharp increase in seroprevalence over a one-year period. This increase is primarily due to the synergistic effect of the infection and the implementation of vaccines against COVID-19. Further studies to assess the persistence of anti-SARS-CoV-2 antibodies are needed.
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spelling pubmed-106198602023-11-02 Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic Manirakiza, Alexandre Malaka, Christian Mossoro-Kpinde, Hermione Dahlia Yambiyo, Brice Martial Mossoro-Kpinde, Christian Diamant Fandema, Emmanuel Niamathe Yakola, Christelle Doyama-Woza, Rodrigue Kangale-Wando, Ida Maxime Kosh Komba, Jess Elliot Nzapali Guiagassomon, Sandra Manuella Bénedicte Namsenei-Dankpea, Lydie Joella-Venus de la Grace Coti-Reckoundji, Cathy Sandra Gomelle Bouhouda, Modeste Gody, Jean-Chrisostome Grésenguet, Gérard Vernet, Guy Vernet, Marie Astrid Nakoune, Emmanuel PLOS Glob Public Health Research Article Healthcare workers (HCWs) are at high to very high risk for SARS-CoV-2 infection. The persistence of this pandemic worldwide has instigated the need for an investigation of the level of prevention through immunization and vaccination against SARS-CoV-2 among HCWs. The objective of our study was to evaluate any changes in anti-COVID-19 serological status before and after the vaccination campaign of health personnel in the Central African Republic. We carried out a repeated cross-sectional serological study on HCWs at the university hospital centers of Bangui. Blood samples were collected and tested for anti-SARS-CoV-2 IgM and IgG using the ELISA technique on blood samples. A total of 179 and 141 HCWs were included in the first and second surveys, respectively. Of these staff, 31.8% of HCWs were positive for anti-SARS-CoV-2 IgG in the first survey, whereas 95.7% were positive for anti-SARS-CoV-2 IgG in the second survey. However, the proportion of HCWs positive for SARS-CoV-2 IgM antibodies was low (9.7% in the first survey and 3.6% in the second survey). These findings showed a sharp increase in seroprevalence over a one-year period. This increase is primarily due to the synergistic effect of the infection and the implementation of vaccines against COVID-19. Further studies to assess the persistence of anti-SARS-CoV-2 antibodies are needed. Public Library of Science 2023-11-01 /pmc/articles/PMC10619860/ /pubmed/37910467 http://dx.doi.org/10.1371/journal.pgph.0001497 Text en © 2023 Manirakiza et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Manirakiza, Alexandre
Malaka, Christian
Mossoro-Kpinde, Hermione Dahlia
Yambiyo, Brice Martial
Mossoro-Kpinde, Christian Diamant
Fandema, Emmanuel
Niamathe Yakola, Christelle
Doyama-Woza, Rodrigue
Kangale-Wando, Ida Maxime
Kosh Komba, Jess Elliot
Nzapali Guiagassomon, Sandra Manuella Bénedicte
Namsenei-Dankpea, Lydie Joella-Venus de la Grace
Coti-Reckoundji, Cathy Sandra Gomelle
Bouhouda, Modeste
Gody, Jean-Chrisostome
Grésenguet, Gérard
Vernet, Guy
Vernet, Marie Astrid
Nakoune, Emmanuel
Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic
title Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic
title_full Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic
title_fullStr Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic
title_full_unstemmed Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic
title_short Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic
title_sort seroprevalence of anti-sars-cov-2 antibodies before and after implementation of anti-covid-19 vaccination among hospital staff in bangui, central african republic
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619860/
https://www.ncbi.nlm.nih.gov/pubmed/37910467
http://dx.doi.org/10.1371/journal.pgph.0001497
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