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The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases

Adipose tissue is the most important energy storage organ in the body, maintaining its normal energy metabolism function and playing a vital role in keeping the energy balance of the body to avoid the harm caused by obesity and a series of related diseases resulting from abnormal energy metabolism....

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Autores principales: Song, Hongbing, Zhang, Xiaohan, Wang, Jing, Wu, Yanling, Xiong, Taimin, Shen, Jieqiong, Lin, Ruiyi, Xiao, Tianfang, Lin, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619862/
https://www.ncbi.nlm.nih.gov/pubmed/37920803
http://dx.doi.org/10.3389/fphys.2023.1261204
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author Song, Hongbing
Zhang, Xiaohan
Wang, Jing
Wu, Yanling
Xiong, Taimin
Shen, Jieqiong
Lin, Ruiyi
Xiao, Tianfang
Lin, Weimin
author_facet Song, Hongbing
Zhang, Xiaohan
Wang, Jing
Wu, Yanling
Xiong, Taimin
Shen, Jieqiong
Lin, Ruiyi
Xiao, Tianfang
Lin, Weimin
author_sort Song, Hongbing
collection PubMed
description Adipose tissue is the most important energy storage organ in the body, maintaining its normal energy metabolism function and playing a vital role in keeping the energy balance of the body to avoid the harm caused by obesity and a series of related diseases resulting from abnormal energy metabolism. The dysfunction of adipose tissue is closely related to the occurrence of diseases related to obesity metabolism. Among various organelles, mitochondria are the main site of energy metabolism, and mitochondria maintain their quality through autophagy, biogenesis, transfer, and dynamics, which play an important role in maintaining metabolic homeostasis of adipocytes. On the other hand, mitochondria have mitochondrial genomes which are vulnerable to damage due to the lack of protective structures and their proximity to sites of reactive oxygen species generation, thus affecting mitochondrial function. Notably, mitochondria are closely related to other organelles in adipocytes, such as lipid droplets and the endoplasmic reticulum, which enhances the function of mitochondria and other organelles and regulates energy metabolism processes, thus reducing the occurrence of obesity-related diseases. This article introduces the structure and quality control of mitochondria in adipocytes and their interactions with other organelles in adipocytes, aiming to provide a new perspective on the regulation of mitochondrial homeostasis in adipocytes on the occurrence of obesity-related diseases, and to provide theoretical reference for further revealing the molecular mechanism of mitochondrial homeostasis in adipocytes on the occurrence of obesity-related diseases.
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spelling pubmed-106198622023-11-02 The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases Song, Hongbing Zhang, Xiaohan Wang, Jing Wu, Yanling Xiong, Taimin Shen, Jieqiong Lin, Ruiyi Xiao, Tianfang Lin, Weimin Front Physiol Physiology Adipose tissue is the most important energy storage organ in the body, maintaining its normal energy metabolism function and playing a vital role in keeping the energy balance of the body to avoid the harm caused by obesity and a series of related diseases resulting from abnormal energy metabolism. The dysfunction of adipose tissue is closely related to the occurrence of diseases related to obesity metabolism. Among various organelles, mitochondria are the main site of energy metabolism, and mitochondria maintain their quality through autophagy, biogenesis, transfer, and dynamics, which play an important role in maintaining metabolic homeostasis of adipocytes. On the other hand, mitochondria have mitochondrial genomes which are vulnerable to damage due to the lack of protective structures and their proximity to sites of reactive oxygen species generation, thus affecting mitochondrial function. Notably, mitochondria are closely related to other organelles in adipocytes, such as lipid droplets and the endoplasmic reticulum, which enhances the function of mitochondria and other organelles and regulates energy metabolism processes, thus reducing the occurrence of obesity-related diseases. This article introduces the structure and quality control of mitochondria in adipocytes and their interactions with other organelles in adipocytes, aiming to provide a new perspective on the regulation of mitochondrial homeostasis in adipocytes on the occurrence of obesity-related diseases, and to provide theoretical reference for further revealing the molecular mechanism of mitochondrial homeostasis in adipocytes on the occurrence of obesity-related diseases. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10619862/ /pubmed/37920803 http://dx.doi.org/10.3389/fphys.2023.1261204 Text en Copyright © 2023 Song, Zhang, Wang, Wu, Xiong, Shen, Lin, Xiao and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Song, Hongbing
Zhang, Xiaohan
Wang, Jing
Wu, Yanling
Xiong, Taimin
Shen, Jieqiong
Lin, Ruiyi
Xiao, Tianfang
Lin, Weimin
The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases
title The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases
title_full The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases
title_fullStr The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases
title_full_unstemmed The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases
title_short The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases
title_sort regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619862/
https://www.ncbi.nlm.nih.gov/pubmed/37920803
http://dx.doi.org/10.3389/fphys.2023.1261204
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