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Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces

OBJECTIVE: This study aimed to explore the association between cerebral hemodynamic parameters focused on the critical closing pressure (CCP) and enlarged perivascular spaces (EPVS). METHODS: Cerebral blood velocity in the middle cerebral artery (MCAv) and non-invasive continuous blood pressure (NIB...

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Autores principales: Zhong, Jiayi, Lin, Wanrong, Chen, Junru, Gao, Qingchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619908/
https://www.ncbi.nlm.nih.gov/pubmed/37920831
http://dx.doi.org/10.3389/fneur.2023.1165469
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author Zhong, Jiayi
Lin, Wanrong
Chen, Junru
Gao, Qingchun
author_facet Zhong, Jiayi
Lin, Wanrong
Chen, Junru
Gao, Qingchun
author_sort Zhong, Jiayi
collection PubMed
description OBJECTIVE: This study aimed to explore the association between cerebral hemodynamic parameters focused on the critical closing pressure (CCP) and enlarged perivascular spaces (EPVS). METHODS: Cerebral blood velocity in the middle cerebral artery (MCAv) and non-invasive continuous blood pressure (NIBP) were measured using a transcranial Doppler (TCD) and Finometer, followed by the calculation of cerebral hemodynamic parameters including CCP, resistance area product (RAP), pulsatility index (PI), and pulse pressure (PP). EPVS were graded separately in the basal ganglia (BG) and centrum semiovale (CSO), using a visual semiquantitative ordinal scale. Patients with EPVS >10 were classified into the severe BG-EPVS group and severe CSO-EPVS group, and the remainder into the mild BG-EPVS group and the mild CSO-EPVS group. Spearman’s correlation and binary logistic regression analysis were performed to analyze the relationship between hemodynamic parameters and BG-EPVS and CSO-EPVS, respectively. RESULTS: Overall, 107 patients were enrolled. The severe BG-EPVS group had higher CCP, mean arterial blood pressure (MABP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) than that in the mild BG-EPVS group (p < 0.05). There was no statistical difference in hemodynamic parameters between the severe CSO-EPVS group and the mild CSO-EPVS group. Spearman’s correlation analysis showed that CCP was positively associated with BG-EPVS (rho = 0.331, p < 0.001) and CSO-EPVS (rho = 0.154, p = 0.044). The binary logistic regression analysis showed that CCP was independently associated with severe BG-EPVS (p < 0.05) and not with CSO-EPVS (p > 0.05) after adjusting for confounders. CONCLUSION: CCP representing cerebrovascular tension was independently associated with BG-EPVS.
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spelling pubmed-106199082023-11-02 Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces Zhong, Jiayi Lin, Wanrong Chen, Junru Gao, Qingchun Front Neurol Neurology OBJECTIVE: This study aimed to explore the association between cerebral hemodynamic parameters focused on the critical closing pressure (CCP) and enlarged perivascular spaces (EPVS). METHODS: Cerebral blood velocity in the middle cerebral artery (MCAv) and non-invasive continuous blood pressure (NIBP) were measured using a transcranial Doppler (TCD) and Finometer, followed by the calculation of cerebral hemodynamic parameters including CCP, resistance area product (RAP), pulsatility index (PI), and pulse pressure (PP). EPVS were graded separately in the basal ganglia (BG) and centrum semiovale (CSO), using a visual semiquantitative ordinal scale. Patients with EPVS >10 were classified into the severe BG-EPVS group and severe CSO-EPVS group, and the remainder into the mild BG-EPVS group and the mild CSO-EPVS group. Spearman’s correlation and binary logistic regression analysis were performed to analyze the relationship between hemodynamic parameters and BG-EPVS and CSO-EPVS, respectively. RESULTS: Overall, 107 patients were enrolled. The severe BG-EPVS group had higher CCP, mean arterial blood pressure (MABP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) than that in the mild BG-EPVS group (p < 0.05). There was no statistical difference in hemodynamic parameters between the severe CSO-EPVS group and the mild CSO-EPVS group. Spearman’s correlation analysis showed that CCP was positively associated with BG-EPVS (rho = 0.331, p < 0.001) and CSO-EPVS (rho = 0.154, p = 0.044). The binary logistic regression analysis showed that CCP was independently associated with severe BG-EPVS (p < 0.05) and not with CSO-EPVS (p > 0.05) after adjusting for confounders. CONCLUSION: CCP representing cerebrovascular tension was independently associated with BG-EPVS. Frontiers Media S.A. 2023-10-05 /pmc/articles/PMC10619908/ /pubmed/37920831 http://dx.doi.org/10.3389/fneur.2023.1165469 Text en Copyright © 2023 Zhong, Lin, Chen and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhong, Jiayi
Lin, Wanrong
Chen, Junru
Gao, Qingchun
Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces
title Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces
title_full Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces
title_fullStr Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces
title_full_unstemmed Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces
title_short Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces
title_sort higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619908/
https://www.ncbi.nlm.nih.gov/pubmed/37920831
http://dx.doi.org/10.3389/fneur.2023.1165469
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