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Herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis

Objectives: Chronic cough is a frequent condition worldwide that significantly impairs quality of life. Herbal medicine (HM) has been used to treat chronic cough due to the limited effectiveness of conventional medications. This study aimed to summarize and determine the effects of HM on patients wi...

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Autores principales: Lee, Boram, Kwon, Chan-Young, Suh, Hyo-Weon, Kim, Ye Ji, Kim, Kwan-Il, Lee, Beom-Joon, Lee, Jun-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619915/
https://www.ncbi.nlm.nih.gov/pubmed/37920213
http://dx.doi.org/10.3389/fphar.2023.1230604
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author Lee, Boram
Kwon, Chan-Young
Suh, Hyo-Weon
Kim, Ye Ji
Kim, Kwan-Il
Lee, Beom-Joon
Lee, Jun-Hwan
author_facet Lee, Boram
Kwon, Chan-Young
Suh, Hyo-Weon
Kim, Ye Ji
Kim, Kwan-Il
Lee, Beom-Joon
Lee, Jun-Hwan
author_sort Lee, Boram
collection PubMed
description Objectives: Chronic cough is a frequent condition worldwide that significantly impairs quality of life. Herbal medicine (HM) has been used to treat chronic cough due to the limited effectiveness of conventional medications. This study aimed to summarize and determine the effects of HM on patients with chronic cough. Methods: A comprehensive search of 11 databases was conducted to find randomized controlled clinical trials (RCTs) that reported the effects of HM for patients with chronic cough on 16 March 2023. The primary outcome was cough severity, and the secondary outcomes included cough-related quality of life, cough frequency, total effective rate (TER), and cough recurrence rate. The methodological quality of the included studies was assessed using the Cochrane risk of bias tool, and the certainty of the evidence for effect estimates was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations tool. Results: A total of 80 RCTs comprising 7,573 patients were included. When HM was used as an alternative therapy to conventional medication, there were inconsistent results in improving cough severity. However, HM significantly improved cough-related quality of life and TER and significantly lowered the cough recurrence rate compared with conventional medication. When used as an add-on therapy to conventional medication, HM significantly improved cough severity, cough-related quality of life, and TER and significantly lowered the recurrence rate. In addition, HM had a significantly lower incidence of adverse events when used as an add-on or alternative therapy to conventional medication. The subgroup analysis according to age and cause of cough also showed a statistically consistent correlation with the overall results. The certainty of the evidence for the effect of HM was generally moderate to low due to the risk of bias in the included studies. Conclusion: HM may improve cough severity and cough-related quality of life, and lower the cough recurrence rate and incidence of adverse events in patients with chronic cough. However, due to the high risk of bias and clinical heterogeneity of the included studies, further high-quality placebo-controlled clinical trials should be conducted using a validated and objective assessment tool. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023418736, CRD42023418736.
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spelling pubmed-106199152023-11-02 Herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis Lee, Boram Kwon, Chan-Young Suh, Hyo-Weon Kim, Ye Ji Kim, Kwan-Il Lee, Beom-Joon Lee, Jun-Hwan Front Pharmacol Pharmacology Objectives: Chronic cough is a frequent condition worldwide that significantly impairs quality of life. Herbal medicine (HM) has been used to treat chronic cough due to the limited effectiveness of conventional medications. This study aimed to summarize and determine the effects of HM on patients with chronic cough. Methods: A comprehensive search of 11 databases was conducted to find randomized controlled clinical trials (RCTs) that reported the effects of HM for patients with chronic cough on 16 March 2023. The primary outcome was cough severity, and the secondary outcomes included cough-related quality of life, cough frequency, total effective rate (TER), and cough recurrence rate. The methodological quality of the included studies was assessed using the Cochrane risk of bias tool, and the certainty of the evidence for effect estimates was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations tool. Results: A total of 80 RCTs comprising 7,573 patients were included. When HM was used as an alternative therapy to conventional medication, there were inconsistent results in improving cough severity. However, HM significantly improved cough-related quality of life and TER and significantly lowered the cough recurrence rate compared with conventional medication. When used as an add-on therapy to conventional medication, HM significantly improved cough severity, cough-related quality of life, and TER and significantly lowered the recurrence rate. In addition, HM had a significantly lower incidence of adverse events when used as an add-on or alternative therapy to conventional medication. The subgroup analysis according to age and cause of cough also showed a statistically consistent correlation with the overall results. The certainty of the evidence for the effect of HM was generally moderate to low due to the risk of bias in the included studies. Conclusion: HM may improve cough severity and cough-related quality of life, and lower the cough recurrence rate and incidence of adverse events in patients with chronic cough. However, due to the high risk of bias and clinical heterogeneity of the included studies, further high-quality placebo-controlled clinical trials should be conducted using a validated and objective assessment tool. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023418736, CRD42023418736. Frontiers Media S.A. 2023-10-17 /pmc/articles/PMC10619915/ /pubmed/37920213 http://dx.doi.org/10.3389/fphar.2023.1230604 Text en Copyright © 2023 Lee, Kwon, Suh, Kim, Kim, Lee and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lee, Boram
Kwon, Chan-Young
Suh, Hyo-Weon
Kim, Ye Ji
Kim, Kwan-Il
Lee, Beom-Joon
Lee, Jun-Hwan
Herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis
title Herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis
title_full Herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis
title_fullStr Herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis
title_full_unstemmed Herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis
title_short Herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis
title_sort herbal medicine for the treatment of chronic cough: a systematic review and meta-analysis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619915/
https://www.ncbi.nlm.nih.gov/pubmed/37920213
http://dx.doi.org/10.3389/fphar.2023.1230604
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