Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers

Ovarian cancer (OC) is a lethal gynecologic malignancy, with modest responses to CPI. Engagement of additional immune arms, such as NK cells, may be of value. We focused on Siglec-7 as a surface antigen for engaging this population. Human antibodies against Siglec-7 were developed and characterized....

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Detalles Bibliográficos
Autores principales: Bordoloi, Devivasha, Kulkarni, Abhijeet J., Adeniji, Opeyemi S., Pampena, M. Betina, Bhojnagarwala, Pratik S., Zhao, Shushu, Ionescu, Candice, Perales-Puchalt, Alfredo, Parzych, Elizabeth M., Zhu, Xizhou, Ali, Ali R., Cassel, Joel, Zhang, Rugang, Betts, Michael R., Abdel-Mohsen, Mohamed, Weiner, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619929/
https://www.ncbi.nlm.nih.gov/pubmed/37910620
http://dx.doi.org/10.1126/sciadv.adh4379

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