Autoinhibited kinesin-1 adopts a hierarchical folding pattern

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Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 remains unknown. Here, we combine crosslinking mas...

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Detalles Bibliográficos
Autores principales: Tan, Zhenyu, Yue, Yang, Leprevost, Felipe, Haynes, Sarah, Basrur, Venkatesha, Nesvizhskii, Alexey I, Verhey, Kristen J, Cianfrocco, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619981/
https://www.ncbi.nlm.nih.gov/pubmed/37910016
http://dx.doi.org/10.7554/eLife.86776
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