Genetic inhibitors of APOBEC3B-induced mutagenesis

The cytidine deaminases APOBEC3A (A3A) and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we used a screen to identify 61 gene deletions that increase A3B-induced mutations in yeast. We...

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Detalles Bibliográficos
Autores principales: Mertz, Tony M., Rice-Reynolds, Elizabeth, Nguyen, Ly, Wood, Anna, Cordero, Cameron, Bray, Nicholas, Harcy, Victoria, Vyas, Rudri K., Mitchell, Debra, Lobachev, Kirill, Roberts, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620048/
https://www.ncbi.nlm.nih.gov/pubmed/37532520
http://dx.doi.org/10.1101/gr.277430.122

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