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ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development

MicroRNAs (miRNAs) pair to sites in mRNAs to direct the degradation of these RNA transcripts. Conversely, certain RNA transcripts can direct the degradation of particular miRNAs. This target-directed miRNA degradation (TDMD) requires the ZSWIM8 E3 ubiquitin ligase. Here, we report the function of ZS...

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Detalles Bibliográficos
Autores principales:	Shi, Charlie Y., Elcavage, Lara E., Chivukula, Raghu R., Stefano, Joanna, Kleaveland, Benjamin, Bartel, David P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620050/ https://www.ncbi.nlm.nih.gov/pubmed/37532519 http://dx.doi.org/10.1101/gr.278073.123

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