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Activity map of a cortico-cerebellar loop underlying motor planning
The neocortex and cerebellum interact to mediate cognitive functions. It remains unknown how the two structures organize into functional networks to mediate specific behaviors. Here we delineate activity supporting motor planning in relation to the mesoscale cortico-cerebellar connectome. In mice pl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620095/ https://www.ncbi.nlm.nih.gov/pubmed/37814026 http://dx.doi.org/10.1038/s41593-023-01453-x |
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author | Zhu, Jia Hasanbegović, Hana Liu, Liu D. Gao, Zhenyu Li, Nuo |
author_facet | Zhu, Jia Hasanbegović, Hana Liu, Liu D. Gao, Zhenyu Li, Nuo |
author_sort | Zhu, Jia |
collection | PubMed |
description | The neocortex and cerebellum interact to mediate cognitive functions. It remains unknown how the two structures organize into functional networks to mediate specific behaviors. Here we delineate activity supporting motor planning in relation to the mesoscale cortico-cerebellar connectome. In mice planning directional licking based on short-term memory, preparatory activity instructing future movement depends on the anterior lateral motor cortex (ALM) and the cerebellum. Transneuronal tracing revealed divergent and largely open-loop connectivity between the ALM and distributed regions of the cerebellum. A cerebellum-wide survey of neuronal activity revealed enriched preparatory activity in hotspot regions with conjunctive input–output connectivity to the ALM. Perturbation experiments show that the conjunction regions were required for maintaining preparatory activity and correct subsequent movement. Other cerebellar regions contributed little to motor planning despite input or output connectivity to the ALM. These results identify a functional cortico-cerebellar loop and suggest the cerebellar cortex selectively establishes reciprocal cortico-cerebellar communications to orchestrate motor planning. |
format | Online Article Text |
id | pubmed-10620095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-106200952023-11-03 Activity map of a cortico-cerebellar loop underlying motor planning Zhu, Jia Hasanbegović, Hana Liu, Liu D. Gao, Zhenyu Li, Nuo Nat Neurosci Article The neocortex and cerebellum interact to mediate cognitive functions. It remains unknown how the two structures organize into functional networks to mediate specific behaviors. Here we delineate activity supporting motor planning in relation to the mesoscale cortico-cerebellar connectome. In mice planning directional licking based on short-term memory, preparatory activity instructing future movement depends on the anterior lateral motor cortex (ALM) and the cerebellum. Transneuronal tracing revealed divergent and largely open-loop connectivity between the ALM and distributed regions of the cerebellum. A cerebellum-wide survey of neuronal activity revealed enriched preparatory activity in hotspot regions with conjunctive input–output connectivity to the ALM. Perturbation experiments show that the conjunction regions were required for maintaining preparatory activity and correct subsequent movement. Other cerebellar regions contributed little to motor planning despite input or output connectivity to the ALM. These results identify a functional cortico-cerebellar loop and suggest the cerebellar cortex selectively establishes reciprocal cortico-cerebellar communications to orchestrate motor planning. Nature Publishing Group US 2023-10-09 2023 /pmc/articles/PMC10620095/ /pubmed/37814026 http://dx.doi.org/10.1038/s41593-023-01453-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhu, Jia Hasanbegović, Hana Liu, Liu D. Gao, Zhenyu Li, Nuo Activity map of a cortico-cerebellar loop underlying motor planning |
title | Activity map of a cortico-cerebellar loop underlying motor planning |
title_full | Activity map of a cortico-cerebellar loop underlying motor planning |
title_fullStr | Activity map of a cortico-cerebellar loop underlying motor planning |
title_full_unstemmed | Activity map of a cortico-cerebellar loop underlying motor planning |
title_short | Activity map of a cortico-cerebellar loop underlying motor planning |
title_sort | activity map of a cortico-cerebellar loop underlying motor planning |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620095/ https://www.ncbi.nlm.nih.gov/pubmed/37814026 http://dx.doi.org/10.1038/s41593-023-01453-x |
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