Toxic PARP trapping upon cAMP-induced DNA damage reinstates the efficacy of endocrine therapy and CDK4/6 inhibitors in treatment-refractory ER+ breast cancer

Resistance to endocrine therapy and CDK4/6 inhibitors, the standard of care (SOC) in estrogen receptor-positive (ER+) breast cancer, greatly reduces patient survival. Therefore, elucidating the mechanisms of sensitivity and resistance to SOC therapy and identifying actionable targets are urgently ne...

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Detalles Bibliográficos
Autores principales: Saatci, Ozge, Cetin, Metin, Uner, Meral, Tokat, Unal Metin, Chatzistamou, Ioulia, Ersan, Pelin Gulizar, Montaudon, Elodie, Akyol, Aytekin, Aksoy, Sercan, Uner, Aysegul, Marangoni, Elisabetta, Sajish, Mathew, Sahin, Ozgur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620179/
https://www.ncbi.nlm.nih.gov/pubmed/37914699
http://dx.doi.org/10.1038/s41467-023-42736-y

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