Cargando…
Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults
Metabolic syndrome (MetS) is characterized by metabolic dysfunctions and could predict future risk for cardiovascular diseases (CVDs). However, the traditionally defined dichotomous MetS neither reflected MetS severity nor considered demographic variations. Here we develop a continuous, age-sex-ethn...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620391/ https://www.ncbi.nlm.nih.gov/pubmed/37914709 http://dx.doi.org/10.1038/s41467-023-42423-y |
_version_ | 1785130195285442560 |
---|---|
author | Yang, Shujuan Yu, Bin Yu, Wanqi Dai, Shaoqing Feng, Chuanteng Shao, Ying Zhao, Xing Li, Xiaoqing He, Tianjing Jia, Peng |
author_facet | Yang, Shujuan Yu, Bin Yu, Wanqi Dai, Shaoqing Feng, Chuanteng Shao, Ying Zhao, Xing Li, Xiaoqing He, Tianjing Jia, Peng |
author_sort | Yang, Shujuan |
collection | PubMed |
description | Metabolic syndrome (MetS) is characterized by metabolic dysfunctions and could predict future risk for cardiovascular diseases (CVDs). However, the traditionally defined dichotomous MetS neither reflected MetS severity nor considered demographic variations. Here we develop a continuous, age-sex-ethnicity-specific MetS score based on continuous measures of the five metabolic dysfunctions (waist circumference [WC], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], mean arterial pressure [MAP], and fasting blood glucose [FBG]). We find that the weights of metabolic dysfunctions in the score vary across age-sex-ethnicity-specific subgroups, with higher weights for TG, HDL-C, and WC. Each unit increase in the score is associated with increased risks for hyperlipidemia, diabetes, and hypertension, and elevated levels of HbA1c, cholesterol, body mass index, and serum uric acid. The score shows high sensitivity and accuracy for detecting CVD-related risk factors and is validated in different geographical regions. Our study would advance early identification of CVD risks and, more broadly, preventive medicine and sustainable development goals. |
format | Online Article Text |
id | pubmed-10620391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106203912023-11-03 Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults Yang, Shujuan Yu, Bin Yu, Wanqi Dai, Shaoqing Feng, Chuanteng Shao, Ying Zhao, Xing Li, Xiaoqing He, Tianjing Jia, Peng Nat Commun Article Metabolic syndrome (MetS) is characterized by metabolic dysfunctions and could predict future risk for cardiovascular diseases (CVDs). However, the traditionally defined dichotomous MetS neither reflected MetS severity nor considered demographic variations. Here we develop a continuous, age-sex-ethnicity-specific MetS score based on continuous measures of the five metabolic dysfunctions (waist circumference [WC], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], mean arterial pressure [MAP], and fasting blood glucose [FBG]). We find that the weights of metabolic dysfunctions in the score vary across age-sex-ethnicity-specific subgroups, with higher weights for TG, HDL-C, and WC. Each unit increase in the score is associated with increased risks for hyperlipidemia, diabetes, and hypertension, and elevated levels of HbA1c, cholesterol, body mass index, and serum uric acid. The score shows high sensitivity and accuracy for detecting CVD-related risk factors and is validated in different geographical regions. Our study would advance early identification of CVD risks and, more broadly, preventive medicine and sustainable development goals. Nature Publishing Group UK 2023-11-01 /pmc/articles/PMC10620391/ /pubmed/37914709 http://dx.doi.org/10.1038/s41467-023-42423-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yang, Shujuan Yu, Bin Yu, Wanqi Dai, Shaoqing Feng, Chuanteng Shao, Ying Zhao, Xing Li, Xiaoqing He, Tianjing Jia, Peng Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults |
title | Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults |
title_full | Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults |
title_fullStr | Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults |
title_full_unstemmed | Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults |
title_short | Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults |
title_sort | development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the chinese adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620391/ https://www.ncbi.nlm.nih.gov/pubmed/37914709 http://dx.doi.org/10.1038/s41467-023-42423-y |
work_keys_str_mv | AT yangshujuan developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT yubin developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT yuwanqi developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT daishaoqing developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT fengchuanteng developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT shaoying developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT zhaoxing developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT lixiaoqing developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT hetianjing developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults AT jiapeng developmentandvalidationofanagesexethnicityspecificmetabolicsyndromescoreinthechineseadults |