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Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans

Average beat interval (BI) and beat interval variability (BIV) are primarily determined by mutual entrainment between the autonomic-nervous system (ANS) and intrinsic mechanisms that govern sinoatrial node (SAN) cell function. While basal heart rate is not affected by age in humans, age-dependent re...

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Autores principales: Weiser-Bitoun, Ido, Mori, Hitoshi, Nabeshima, Taisuke, Tanaka, Naomichi, Kudo, Daisuke, Sasaki, Wataru, Narita, Masataka, Matsumoto, Kazuhisa, Ikeda, Yoshifumi, Arai, Takahide, Nakano, Shintaro, Sumitomo, Naokata, Senbonmatsu, Taka-aki, Matsumoto, Kazuo, Kato, Ritsushi, Morrell, Christopher H., Tsutsui, Kenta, Yaniv, Yael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620402/
https://www.ncbi.nlm.nih.gov/pubmed/37914708
http://dx.doi.org/10.1038/s41598-023-45101-7
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author Weiser-Bitoun, Ido
Mori, Hitoshi
Nabeshima, Taisuke
Tanaka, Naomichi
Kudo, Daisuke
Sasaki, Wataru
Narita, Masataka
Matsumoto, Kazuhisa
Ikeda, Yoshifumi
Arai, Takahide
Nakano, Shintaro
Sumitomo, Naokata
Senbonmatsu, Taka-aki
Matsumoto, Kazuo
Kato, Ritsushi
Morrell, Christopher H.
Tsutsui, Kenta
Yaniv, Yael
author_facet Weiser-Bitoun, Ido
Mori, Hitoshi
Nabeshima, Taisuke
Tanaka, Naomichi
Kudo, Daisuke
Sasaki, Wataru
Narita, Masataka
Matsumoto, Kazuhisa
Ikeda, Yoshifumi
Arai, Takahide
Nakano, Shintaro
Sumitomo, Naokata
Senbonmatsu, Taka-aki
Matsumoto, Kazuo
Kato, Ritsushi
Morrell, Christopher H.
Tsutsui, Kenta
Yaniv, Yael
author_sort Weiser-Bitoun, Ido
collection PubMed
description Average beat interval (BI) and beat interval variability (BIV) are primarily determined by mutual entrainment between the autonomic-nervous system (ANS) and intrinsic mechanisms that govern sinoatrial node (SAN) cell function. While basal heart rate is not affected by age in humans, age-dependent reductions in intrinsic heart rate have been documented even in so-called healthy individuals. The relative contributions of the ANS and intrinsic mechanisms to age-dependent deterioration of SAN function in humans are not clear. We recorded ECG on patients (n = 16 < 21 years and n = 23 41–78 years) in the basal state and after ANS blockade (propranolol and atropine) in the presence of propofol and dexmedetomidine anesthesia. Average BI and BIV were analyzed. A set of BIV features were tested to designated the “signatures” of the ANS and intrinsic mechanisms and also the anesthesia “signature”. In young patients, the intrinsic mechanisms and ANS mainly contributed to long- and short-term BIV, respectively. In adults, both ANS and intrinsic mechanisms contributed to short-term BIV, while the latter also contributed to long-term BIV. Furthermore, anesthesia affected ANS function in young patients and both mechanisms in adult. The work also showed that intrinsic mechanism features can be calculated from BIs, without intervention.
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spelling pubmed-106204022023-11-03 Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans Weiser-Bitoun, Ido Mori, Hitoshi Nabeshima, Taisuke Tanaka, Naomichi Kudo, Daisuke Sasaki, Wataru Narita, Masataka Matsumoto, Kazuhisa Ikeda, Yoshifumi Arai, Takahide Nakano, Shintaro Sumitomo, Naokata Senbonmatsu, Taka-aki Matsumoto, Kazuo Kato, Ritsushi Morrell, Christopher H. Tsutsui, Kenta Yaniv, Yael Sci Rep Article Average beat interval (BI) and beat interval variability (BIV) are primarily determined by mutual entrainment between the autonomic-nervous system (ANS) and intrinsic mechanisms that govern sinoatrial node (SAN) cell function. While basal heart rate is not affected by age in humans, age-dependent reductions in intrinsic heart rate have been documented even in so-called healthy individuals. The relative contributions of the ANS and intrinsic mechanisms to age-dependent deterioration of SAN function in humans are not clear. We recorded ECG on patients (n = 16 < 21 years and n = 23 41–78 years) in the basal state and after ANS blockade (propranolol and atropine) in the presence of propofol and dexmedetomidine anesthesia. Average BI and BIV were analyzed. A set of BIV features were tested to designated the “signatures” of the ANS and intrinsic mechanisms and also the anesthesia “signature”. In young patients, the intrinsic mechanisms and ANS mainly contributed to long- and short-term BIV, respectively. In adults, both ANS and intrinsic mechanisms contributed to short-term BIV, while the latter also contributed to long-term BIV. Furthermore, anesthesia affected ANS function in young patients and both mechanisms in adult. The work also showed that intrinsic mechanism features can be calculated from BIs, without intervention. Nature Publishing Group UK 2023-11-01 /pmc/articles/PMC10620402/ /pubmed/37914708 http://dx.doi.org/10.1038/s41598-023-45101-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Weiser-Bitoun, Ido
Mori, Hitoshi
Nabeshima, Taisuke
Tanaka, Naomichi
Kudo, Daisuke
Sasaki, Wataru
Narita, Masataka
Matsumoto, Kazuhisa
Ikeda, Yoshifumi
Arai, Takahide
Nakano, Shintaro
Sumitomo, Naokata
Senbonmatsu, Taka-aki
Matsumoto, Kazuo
Kato, Ritsushi
Morrell, Christopher H.
Tsutsui, Kenta
Yaniv, Yael
Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
title Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
title_full Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
title_fullStr Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
title_full_unstemmed Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
title_short Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
title_sort age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620402/
https://www.ncbi.nlm.nih.gov/pubmed/37914708
http://dx.doi.org/10.1038/s41598-023-45101-7
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