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Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide
Introduction: Targeted Radionuclide Therapy is used for the treatment of tumors in nuclear medicine, while sparing healthy tissues. Its application to cancer treatment is expanding. In particular, Auger-electron emitters potentially exhibit high efficacy in treating either small metastases or single...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620610/ https://www.ncbi.nlm.nih.gov/pubmed/37927558 http://dx.doi.org/10.3389/fchem.2023.1288588 |
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author | Renaldin, Edoardo Dellepiane, Gaia Braccini, Saverio Sommerhalder, Alexander Zhang, Hui van der Meulen, Nicholas P. Eichler, Robert Talip, Zeynep |
author_facet | Renaldin, Edoardo Dellepiane, Gaia Braccini, Saverio Sommerhalder, Alexander Zhang, Hui van der Meulen, Nicholas P. Eichler, Robert Talip, Zeynep |
author_sort | Renaldin, Edoardo |
collection | PubMed |
description | Introduction: Targeted Radionuclide Therapy is used for the treatment of tumors in nuclear medicine, while sparing healthy tissues. Its application to cancer treatment is expanding. In particular, Auger-electron emitters potentially exhibit high efficacy in treating either small metastases or single tumor cells due to their short range in tissue. The aim of this paper is to study the feasibility of a large-scale production of thulium-167, an Auger-electron emitter radionuclide, in view of eventual systematic preclinical studies. Methods: Proton-irradiated enriched erbium-167 and erbium-168 oxides were used to measure the production cross sections of thulium-165, thulium-166, thulium-167, and thulium-168 utilizing an 18-MeV medical cyclotron equipped with a Beam Transport Line (BTL) at the Bern medical cyclotron laboratory. The comparison between the experimental and the TENDL 2021 theoretical cross-section results were in good agreement. Additional experiments were performed to assess the production yields of thulium radioisotopes in the BTL. Thulium-167 production yield was also measured irradiating five different target materials ((167) Er (2) O (3), (168) Er (2) O (3), ( nat ) Tm (2) O (3), ( nat ) Yb (2) O (3), (171) Yb (2) O (3)) with proton beams up to 63 MeV at the Injector II cyclotron of Paul Scherrer Institute. Results and Discussion: Our experiments showed that an 8-h irradiation of enriched ytterbium-171 oxide produced about 420 MBq of thulium-167 with a radionuclidic purity of 99.95% after 5 days of cooling time with a proton beam of about 53 MeV. Larger activities of thulium-167 can be achieved using enriched erbium-168 oxide with a 23-MeV proton beam, obtaining about 1 GBq after 8-h irradiation with a radionuclidic purity of [Formula: see text] 99.5% 5 days post end of bombardment. |
format | Online Article Text |
id | pubmed-10620610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106206102023-11-03 Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide Renaldin, Edoardo Dellepiane, Gaia Braccini, Saverio Sommerhalder, Alexander Zhang, Hui van der Meulen, Nicholas P. Eichler, Robert Talip, Zeynep Front Chem Chemistry Introduction: Targeted Radionuclide Therapy is used for the treatment of tumors in nuclear medicine, while sparing healthy tissues. Its application to cancer treatment is expanding. In particular, Auger-electron emitters potentially exhibit high efficacy in treating either small metastases or single tumor cells due to their short range in tissue. The aim of this paper is to study the feasibility of a large-scale production of thulium-167, an Auger-electron emitter radionuclide, in view of eventual systematic preclinical studies. Methods: Proton-irradiated enriched erbium-167 and erbium-168 oxides were used to measure the production cross sections of thulium-165, thulium-166, thulium-167, and thulium-168 utilizing an 18-MeV medical cyclotron equipped with a Beam Transport Line (BTL) at the Bern medical cyclotron laboratory. The comparison between the experimental and the TENDL 2021 theoretical cross-section results were in good agreement. Additional experiments were performed to assess the production yields of thulium radioisotopes in the BTL. Thulium-167 production yield was also measured irradiating five different target materials ((167) Er (2) O (3), (168) Er (2) O (3), ( nat ) Tm (2) O (3), ( nat ) Yb (2) O (3), (171) Yb (2) O (3)) with proton beams up to 63 MeV at the Injector II cyclotron of Paul Scherrer Institute. Results and Discussion: Our experiments showed that an 8-h irradiation of enriched ytterbium-171 oxide produced about 420 MBq of thulium-167 with a radionuclidic purity of 99.95% after 5 days of cooling time with a proton beam of about 53 MeV. Larger activities of thulium-167 can be achieved using enriched erbium-168 oxide with a 23-MeV proton beam, obtaining about 1 GBq after 8-h irradiation with a radionuclidic purity of [Formula: see text] 99.5% 5 days post end of bombardment. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10620610/ /pubmed/37927558 http://dx.doi.org/10.3389/fchem.2023.1288588 Text en Copyright © 2023 Renaldin, Dellepiane, Braccini, Sommerhalder, Zhang, van der Meulen, Eichler and Talip. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Renaldin, Edoardo Dellepiane, Gaia Braccini, Saverio Sommerhalder, Alexander Zhang, Hui van der Meulen, Nicholas P. Eichler, Robert Talip, Zeynep Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide |
title | Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide |
title_full | Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide |
title_fullStr | Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide |
title_full_unstemmed | Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide |
title_short | Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide |
title_sort | study of thulium-167 cyclotron production: a potential medically-relevant radionuclide |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620610/ https://www.ncbi.nlm.nih.gov/pubmed/37927558 http://dx.doi.org/10.3389/fchem.2023.1288588 |
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