Cargando…

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately...

Descripción completa

Detalles Bibliográficos
Autores principales: Ullah, Amin, Zhao, Jing, Singla, Rajeev K., Shen, Bairong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620730/
https://www.ncbi.nlm.nih.gov/pubmed/37928902
http://dx.doi.org/10.3389/fcell.2023.1272536
_version_ 1785130264608899072
author Ullah, Amin
Zhao, Jing
Singla, Rajeev K.
Shen, Bairong
author_facet Ullah, Amin
Zhao, Jing
Singla, Rajeev K.
Shen, Bairong
author_sort Ullah, Amin
collection PubMed
description Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately 3%–5% of pregnancies worldwide. Nevertheless, it is unclear what triggers PE and GDM to develop. Therefore, the development of novel moderator therapy approaches is a crucial advancement. Chemokines regulate physiological defenses and maternal-fetal interaction during healthy and disturbed pregnancies. Chemokines regulate immunity, stem cell trafficking, anti-angiogenesis, and cell attraction. CXC chemokines are usually inflammatory and contribute to numerous reproductive disorders. Fractalkine (CX3CL1) may be membrane-bound or soluble. CX3CL1 aids cell survival during homeostasis and inflammation. Evidence reveals that CXC and CX3CL1 chemokines and their receptors have been the focus of therapeutic discoveries for clinical intervention due to their considerable participation in numerous biological processes. This review aims to give an overview of the functions of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of PE and GDM. Finally, we examined stimulus specificity for CXC and CX3CL1 chemokine expression and synthesis in PE and GDM and preclinical and clinical trials of CXC-based PE and GDM therapies.
format Online
Article
Text
id pubmed-10620730
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-106207302023-11-03 Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus Ullah, Amin Zhao, Jing Singla, Rajeev K. Shen, Bairong Front Cell Dev Biol Cell and Developmental Biology Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately 3%–5% of pregnancies worldwide. Nevertheless, it is unclear what triggers PE and GDM to develop. Therefore, the development of novel moderator therapy approaches is a crucial advancement. Chemokines regulate physiological defenses and maternal-fetal interaction during healthy and disturbed pregnancies. Chemokines regulate immunity, stem cell trafficking, anti-angiogenesis, and cell attraction. CXC chemokines are usually inflammatory and contribute to numerous reproductive disorders. Fractalkine (CX3CL1) may be membrane-bound or soluble. CX3CL1 aids cell survival during homeostasis and inflammation. Evidence reveals that CXC and CX3CL1 chemokines and their receptors have been the focus of therapeutic discoveries for clinical intervention due to their considerable participation in numerous biological processes. This review aims to give an overview of the functions of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of PE and GDM. Finally, we examined stimulus specificity for CXC and CX3CL1 chemokine expression and synthesis in PE and GDM and preclinical and clinical trials of CXC-based PE and GDM therapies. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10620730/ /pubmed/37928902 http://dx.doi.org/10.3389/fcell.2023.1272536 Text en Copyright © 2023 Ullah, Zhao, Singla and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ullah, Amin
Zhao, Jing
Singla, Rajeev K.
Shen, Bairong
Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
title Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
title_full Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
title_fullStr Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
title_full_unstemmed Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
title_short Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
title_sort pathophysiological impact of cxc and cx3cl1 chemokines in preeclampsia and gestational diabetes mellitus
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620730/
https://www.ncbi.nlm.nih.gov/pubmed/37928902
http://dx.doi.org/10.3389/fcell.2023.1272536
work_keys_str_mv AT ullahamin pathophysiologicalimpactofcxcandcx3cl1chemokinesinpreeclampsiaandgestationaldiabetesmellitus
AT zhaojing pathophysiologicalimpactofcxcandcx3cl1chemokinesinpreeclampsiaandgestationaldiabetesmellitus
AT singlarajeevk pathophysiologicalimpactofcxcandcx3cl1chemokinesinpreeclampsiaandgestationaldiabetesmellitus
AT shenbairong pathophysiologicalimpactofcxcandcx3cl1chemokinesinpreeclampsiaandgestationaldiabetesmellitus