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Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620730/ https://www.ncbi.nlm.nih.gov/pubmed/37928902 http://dx.doi.org/10.3389/fcell.2023.1272536 |
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author | Ullah, Amin Zhao, Jing Singla, Rajeev K. Shen, Bairong |
author_facet | Ullah, Amin Zhao, Jing Singla, Rajeev K. Shen, Bairong |
author_sort | Ullah, Amin |
collection | PubMed |
description | Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately 3%–5% of pregnancies worldwide. Nevertheless, it is unclear what triggers PE and GDM to develop. Therefore, the development of novel moderator therapy approaches is a crucial advancement. Chemokines regulate physiological defenses and maternal-fetal interaction during healthy and disturbed pregnancies. Chemokines regulate immunity, stem cell trafficking, anti-angiogenesis, and cell attraction. CXC chemokines are usually inflammatory and contribute to numerous reproductive disorders. Fractalkine (CX3CL1) may be membrane-bound or soluble. CX3CL1 aids cell survival during homeostasis and inflammation. Evidence reveals that CXC and CX3CL1 chemokines and their receptors have been the focus of therapeutic discoveries for clinical intervention due to their considerable participation in numerous biological processes. This review aims to give an overview of the functions of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of PE and GDM. Finally, we examined stimulus specificity for CXC and CX3CL1 chemokine expression and synthesis in PE and GDM and preclinical and clinical trials of CXC-based PE and GDM therapies. |
format | Online Article Text |
id | pubmed-10620730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106207302023-11-03 Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus Ullah, Amin Zhao, Jing Singla, Rajeev K. Shen, Bairong Front Cell Dev Biol Cell and Developmental Biology Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately 3%–5% of pregnancies worldwide. Nevertheless, it is unclear what triggers PE and GDM to develop. Therefore, the development of novel moderator therapy approaches is a crucial advancement. Chemokines regulate physiological defenses and maternal-fetal interaction during healthy and disturbed pregnancies. Chemokines regulate immunity, stem cell trafficking, anti-angiogenesis, and cell attraction. CXC chemokines are usually inflammatory and contribute to numerous reproductive disorders. Fractalkine (CX3CL1) may be membrane-bound or soluble. CX3CL1 aids cell survival during homeostasis and inflammation. Evidence reveals that CXC and CX3CL1 chemokines and their receptors have been the focus of therapeutic discoveries for clinical intervention due to their considerable participation in numerous biological processes. This review aims to give an overview of the functions of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of PE and GDM. Finally, we examined stimulus specificity for CXC and CX3CL1 chemokine expression and synthesis in PE and GDM and preclinical and clinical trials of CXC-based PE and GDM therapies. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10620730/ /pubmed/37928902 http://dx.doi.org/10.3389/fcell.2023.1272536 Text en Copyright © 2023 Ullah, Zhao, Singla and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Ullah, Amin Zhao, Jing Singla, Rajeev K. Shen, Bairong Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus |
title | Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus |
title_full | Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus |
title_fullStr | Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus |
title_full_unstemmed | Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus |
title_short | Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus |
title_sort | pathophysiological impact of cxc and cx3cl1 chemokines in preeclampsia and gestational diabetes mellitus |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620730/ https://www.ncbi.nlm.nih.gov/pubmed/37928902 http://dx.doi.org/10.3389/fcell.2023.1272536 |
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