Cargando…

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFR(WT)/COX-2 inhibitors with docking studies

A novel series of pyrimidine-5-carbonitrile derivatives was designed, synthesized, then evaluated for their cytotoxic activity as novel anti-cancer with dual EGFR(WT)/COX-2 inhibitors. Two compounds 4e and 4f disclosed the highest activity against all NCI60 panel cell lines. They were most potent ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reda, Nada, Elshewy, Ahmed, EL-Askary, Hesham I., Mohamed, Khaled O., Helwa, Amira A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620772/ https://www.ncbi.nlm.nih.gov/pubmed/37928843 http://dx.doi.org/10.1039/d3ra06088h

Ejemplares similares

New Pyrimidine-5-Carbonitriles as COX-2 Inhibitors: Design, Synthesis, Anticancer Screening, Molecular Docking, and In Silico ADME Profile Studies
por: AL-Ghulikah, Hanan A., et al.
Publicado: (2022)

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR(WT) and EGFR(T790M) inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562
por: El-Dydamony, Nehad M., et al.
Publicado: (2022)

Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents
por: Ahmed, Eman A., et al.
Publicado: (2022)

EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones
por: Musa, Arafa, et al.
Publicado: (2022)

Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFR(WT) and EGFR(T790M)
por: Gaber, Ahmed A., et al.
Publicado: (2022)

4-Amino-6-(piperidin-1-yl)pyrimidine-5-carbonitrile
por: Bhat, Radhika, et al.
Publicado: (2020)

Pyrimidines-Based Heterocyclic Compounds: Synthesis, Cytoxicity Evaluation and Molecular Docking
por: El-Atawy, Mohamed A., et al.
Publicado: (2022)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
por: Kumar, Sanjiv, et al.
Publicado: (2017)

Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFR(WT) and EGFR(T790M)
por: O. Aboelez, Moustafa, et al.
Publicado: (2022)

Synthesis of pyrimidine-6-carbonitriles, pyrimidin-5-ones, and tetrahydroquinoline-3-carbonitriles by new superb oxovanadium(V)-[5,10,15,20-tetrakis(pyridinium)-porphyrinato]-tetra(tricyanomethanide) catalyst via anomeric based oxidation
por: Dashteh, Mohammad, et al.
Publicado: (2022)

Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents
por: Kumar, Sanjiv, et al.
Publicado: (2019)

2-Benzylsulfanyl-4-pentyl-6-(phenylsulfanyl)pyrimidine-5-carbonitrile
por: El-Emam, Ali A., et al.
Publicado: (2011)

2-Anilino-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Mohamed, Shaaban K., et al.
Publicado: (2012)

New Anticancer Theobromine Derivative Targeting EGFR(WT) and EGFR(T790M): Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study
por: Tylińska, Beata, et al.
Publicado: (2021)

New pyrimidine-N-β-D-glucosides: synthesis, biological evaluation, and molecular docking investigations
por: KAHRİMAN, Nuran, et al.
Publicado: (2023)

Identification of Novel Cyanopyridones and Pyrido[2,3-d]pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers
por: Saleh, Abdulrahman M., et al.
Publicado: (2023)

Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
por: Hawash, Mohammed, et al.
Publicado: (2023)

7-Chloro-5-(chloromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Xu, Jingli, et al.
Publicado: (2012)

Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFR(T790M) tyrosine kinase inhibitors
por: Aziz, Nada A. A. M., et al.
Publicado: (2022)

Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors
por: Sobh, Eman A., et al.
Publicado: (2023)

Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
por: Abdelgawad, Mohamed A, et al.
Publicado: (2021)

2-Benzylsulfanyl-4-[(4-methylphenyl)sulfanyl]-6-pentylpyrimidine-5-carbonitrile
por: El-Emam, Ali A., et al.
Publicado: (2012)

Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
por: Abdollahi-Basir, Mohammad Hossein, et al.
Publicado: (2021)

Synthesis, Biological Evaluation, DNA Binding, and Molecular Docking of Hybrid 4,6-Dihydrazone Pyrimidine Derivatives as Antitumor Agents
por: Lan, Hairong, et al.
Publicado: (2022)

Synthesis, Molecular Docking and Biological Evaluation of Glycyrrhizin Analogs as Anticancer Agents Targeting EGFR
por: Yang, Yong-An, et al.
Publicado: (2014)

Synthesis and Molecular Docking Study of Novel Pyrimidine Derivatives against COVID-19
por: Alamshany, Zahra M., et al.
Publicado: (2023)

Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-a] pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs
por: Abdallah, Amira EM, et al.
Publicado: (2018)

New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFR(WT) and EGFR(T790M) Inhibitors: Microwave-Assisted Synthesis, Anticancer Evaluation, and Molecular Docking Study
por: Hashem, Heba E., et al.
Publicado: (2022)

7-(2,4-Dichlorophenyl)-2-methylsulfanylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Wen, Li-rong, et al.
Publicado: (2009)

Multifunctional derivatives of pyrimidine-5-carbonitrile and differently substituted carbazoles for doping-free sky-blue OLEDs and luminescent sensors of oxygen
por: Tsiko, Uliana, et al.
Publicado: (2021)

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity
por: Mourad, Mai A. E., et al.
Publicado: (2023)

Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine‐2,4‐diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase
por: Somandi, Khonzisizwe, et al.
Publicado: (2022)

Design, synthesis, in vitro anticancer, molecular docking and SAR studies of new series of pyrrolo[2,3-d]pyrimidine derivatives
por: Sroor, Farid M., et al.
Publicado: (2023)

Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFR(WT), EGFR(T790M), and EGFR(L858R))
por: Abo Al-Hamd, Mahmoud G., et al.
Publicado: (2023)

Molecular docking analysis of curcumin analogues with COX-2
por: Sohilait, Mario Rowan, et al.
Publicado: (2017)

Molecular docking analysis of COX-2 for potential inhibitors
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFR(L858R/T790M) inhibitors
por: Fu, Jianfang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ri1pgbe77hvmer3ss98ce6fb7o