Cargando…

Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea

Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4(+) T cells of both rosacea patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Mengting, Peng, Qinqin, Tan, Zixin, Xu, San, Wang, Yunying, Wu, Aike, Xiao, Wenqin, Wang, Qian, Xie, Hongfu, Li, Ji, Shi, Wei, Deng, Zhili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620828/
https://www.ncbi.nlm.nih.gov/pubmed/37928265
http://dx.doi.org/10.7150/ijbs.86207
Descripción
Sumario:Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4(+) T cells of both rosacea patients and experimental mice. Specifically, AQP3 deletion blocked the development of rosacea-like skin inflammation in model mice with LL37-induced rosacea-like disease. We also present mechanistic evidence showing that AQP3 was essential to the activation of NF-κB signaling and subsequent production of disease-characteristic chemokines in keratinocytes. Moreover, we show that AQP3 was upregulated during T cell differentiation and promotes helper T (Th) 17 differentiation possibly via the activation of STAT3 signaling. Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4(+) T cells acted synergistically and contributed to the inflammation in rosacea.