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Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome

A 6 year-old spayed female Poodle presented with a mandibular mass. Radiographic examination revealed osteolysis from the right mandibular canine to the fourth premolar, along with horizontal bone loss and dorsal displacement of the right mandibular first and second premolars. Skull cone beam comput...

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Autores principales: Kim, Chun-Geun, Lee, Ga-Won, Kim, Hyun Sil, Han, Seung-Yong, Han, Dawool, Park, Hee-Myung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620927/
https://www.ncbi.nlm.nih.gov/pubmed/37929281
http://dx.doi.org/10.3389/fvets.2023.1267222
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author Kim, Chun-Geun
Lee, Ga-Won
Kim, Hyun Sil
Han, Seung-Yong
Han, Dawool
Park, Hee-Myung
author_facet Kim, Chun-Geun
Lee, Ga-Won
Kim, Hyun Sil
Han, Seung-Yong
Han, Dawool
Park, Hee-Myung
author_sort Kim, Chun-Geun
collection PubMed
description A 6 year-old spayed female Poodle presented with a mandibular mass. Radiographic examination revealed osteolysis from the right mandibular canine to the fourth premolar, along with horizontal bone loss and dorsal displacement of the right mandibular first and second premolars. Skull cone beam computed tomography revealed osteolysis at the level of the right mandibular canine and fourth premolar. A destructive bone lesion was observed in the apical area of the right mandibular canine, with mass invasion of the interradicular bone of the right mandibular first molar near the mandibular canal. Consequently, unilateral total mandibulectomy and skin flap surgery were performed. Histopathological examination revealed poorly demarcated and infiltrative neoplastic epithelial cells that formed small islands and trabeculae. Neoplastic cells exhibited the malignant features of cytological atypia and high mitotic activity. Furthermore, the neoplastic epithelial cells frequently showed ghost cell changes and were diagnosed as ghost cell odontogenic carcinoma (GCOC). The dog was followed up for 1 year, during which no severe complications or local recurrence was observed, except for slight mandibular drift, tongue protrusion, and drooling. This case report describes the clinical features, diagnostic imaging, and histologic features of an unreported GCOC in a dog and the favorable outcome following surgical resection.
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spelling pubmed-106209272023-11-03 Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome Kim, Chun-Geun Lee, Ga-Won Kim, Hyun Sil Han, Seung-Yong Han, Dawool Park, Hee-Myung Front Vet Sci Veterinary Science A 6 year-old spayed female Poodle presented with a mandibular mass. Radiographic examination revealed osteolysis from the right mandibular canine to the fourth premolar, along with horizontal bone loss and dorsal displacement of the right mandibular first and second premolars. Skull cone beam computed tomography revealed osteolysis at the level of the right mandibular canine and fourth premolar. A destructive bone lesion was observed in the apical area of the right mandibular canine, with mass invasion of the interradicular bone of the right mandibular first molar near the mandibular canal. Consequently, unilateral total mandibulectomy and skin flap surgery were performed. Histopathological examination revealed poorly demarcated and infiltrative neoplastic epithelial cells that formed small islands and trabeculae. Neoplastic cells exhibited the malignant features of cytological atypia and high mitotic activity. Furthermore, the neoplastic epithelial cells frequently showed ghost cell changes and were diagnosed as ghost cell odontogenic carcinoma (GCOC). The dog was followed up for 1 year, during which no severe complications or local recurrence was observed, except for slight mandibular drift, tongue protrusion, and drooling. This case report describes the clinical features, diagnostic imaging, and histologic features of an unreported GCOC in a dog and the favorable outcome following surgical resection. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10620927/ /pubmed/37929281 http://dx.doi.org/10.3389/fvets.2023.1267222 Text en Copyright © 2023 Kim, Lee, Kim, Han, Han and Park. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Kim, Chun-Geun
Lee, Ga-Won
Kim, Hyun Sil
Han, Seung-Yong
Han, Dawool
Park, Hee-Myung
Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome
title Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome
title_full Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome
title_fullStr Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome
title_full_unstemmed Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome
title_short Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome
title_sort case report: ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620927/
https://www.ncbi.nlm.nih.gov/pubmed/37929281
http://dx.doi.org/10.3389/fvets.2023.1267222
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