DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus

The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP)...

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Autores principales: Wu, Xinna, Zhou, Xuqiang, Wang, Sanying, Mao, Genxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621139/
https://www.ncbi.nlm.nih.gov/pubmed/37915066
http://dx.doi.org/10.1186/s12985-023-02203-y
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author Wu, Xinna
Zhou, Xuqiang
Wang, Sanying
Mao, Genxiang
author_facet Wu, Xinna
Zhou, Xuqiang
Wang, Sanying
Mao, Genxiang
author_sort Wu, Xinna
collection PubMed
description The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory cytokines. Human cytomegalovirus (HCMV) is a ubiquitous pathogen that plays an important role in the senescence process. It has been established that DDR is necessary for HCMV to replicate effectively. This paper reviews the relationship between DDR, cellular senescence, and HCMV, providing new sights for virus-induced senescence (VIS).
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spelling pubmed-106211392023-11-03 DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus Wu, Xinna Zhou, Xuqiang Wang, Sanying Mao, Genxiang Virol J Review The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory cytokines. Human cytomegalovirus (HCMV) is a ubiquitous pathogen that plays an important role in the senescence process. It has been established that DDR is necessary for HCMV to replicate effectively. This paper reviews the relationship between DDR, cellular senescence, and HCMV, providing new sights for virus-induced senescence (VIS). BioMed Central 2023-11-01 /pmc/articles/PMC10621139/ /pubmed/37915066 http://dx.doi.org/10.1186/s12985-023-02203-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wu, Xinna
Zhou, Xuqiang
Wang, Sanying
Mao, Genxiang
DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
title DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
title_full DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
title_fullStr DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
title_full_unstemmed DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
title_short DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
title_sort dna damage response(ddr): a link between cellular senescence and human cytomegalovirus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621139/
https://www.ncbi.nlm.nih.gov/pubmed/37915066
http://dx.doi.org/10.1186/s12985-023-02203-y
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