Cargando…

LncRNA-Gm9866 promotes liver fibrosis by activating TGFβ/Smad signaling via targeting Fam98b

OBJECTIVE: The exact mechanism and target molecules of liver fibrosis have remained largely elusive. Here, we investigated the role of long noncoding RNA Gm9866(lncRNA-Gm9866) on liver fibrosis. METHODS: The transcription of lncRNA-Gm9866 in activated cells and mouse fibrotic livers was determined b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, Xiaomin, Ruan, Xianxian, Yao, Peishan, Yang, Dan, Wu, Xianbin, Zhou, Xia, Jing, Jie, Wei, Dafu, Liang, Yaodan, Zhang, Taicheng, Qin, Shanyu, Jiang, Haixing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621198/ https://www.ncbi.nlm.nih.gov/pubmed/37919785 http://dx.doi.org/10.1186/s12967-023-04642-1

Ejemplares similares

The Long Noncoding RNA Gm9866/Nuclear Factor-κB Axis Promotes Macrophage Polarization
por: Liao, Xiaomin, et al.
Publicado: (2023)

Identification of Timm13 protein translocase of the mitochondrial inner membrane as a potential mediator of liver fibrosis based on bioinformatics and experimental verification
por: Liao, Xiaomin, et al.
Publicado: (2023)

Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients
por: Wu, Xianbin, et al.
Publicado: (2022)

Serum-derived miR-574-5p-containing exosomes contribute to liver fibrosis by activating hepatic stellate cells
por: Zhou, Xia, et al.
Publicado: (2021)

LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling
por: Zhang, Yiming, et al.
Publicado: (2023)

lncRNA-GM targets Foxo1 to promote T cell–mediated autoimmunity
por: Chen, Yali, et al.
Publicado: (2022)

Identification of ZBTB4 as an immunological biomarker that can inhibit the proliferation and invasion of pancreatic cancer
por: Yang, Zhe, et al.
Publicado: (2023)

FAM225B Is a Prognostic lncRNA for Patients with Recurrent Glioblastoma
por: Li, Junsheng, et al.
Publicado: (2020)

TGF-β/SMAD4-Regulated LncRNA-LINP1 Inhibits Epithelial-Mesenchymal Transition in Lung Cancer
por: Zhang, Chong, et al.
Publicado: (2018)

LncRNA np_5318 promotes renal ischemia-reperfusion injury through the TGF-β/Smad signaling pathway
por: Lu, Jing, et al.
Publicado: (2020)

LncRNA FAM83A‐AS1 promotes lung adenocarcinoma progression by enhancing the pre‐mRNA stability of FAM83A
por: Wang, Wenyi, et al.
Publicado: (2021)

YTHDF2 Inhibits the Migration and Invasion of Lung Adenocarcinoma by Negatively Regulating the FAM83D-TGFβ1-SMAD2/3 Pathway
por: Zhao, Teng, et al.
Publicado: (2022)

LncRNA MBNL1-AS1 represses gastric cancer progression via the TGF-β pathway by modulating miR-424-5p/Smad7 axis
por: Su, Jiewen, et al.
Publicado: (2022)

Local Sustained Chemotherapy of Pancreatic Cancer Using Endoscopic Ultrasound-Guided Injection of Biodegradable Thermo-Sensitive Hydrogel
por: Yang, Dan, et al.
Publicado: (2023)

MicroRNA-26a inhibits cell proliferation and invasion by targeting FAM98A in breast cancer
por: Liu, Tan, et al.
Publicado: (2021)

L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway
por: Ma, Xiao, et al.
Publicado: (2022)

The long-noncoding RNA MALAT1 regulates TGF-β/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cells
por: Zhang, Jinqiang, et al.
Publicado: (2020)

Overexpression of lncRNA-Gm2044 in spermatogonia impairs spermatogenesis in partial seminiferous tubules
por: Hu, Ke, et al.
Publicado: (2022)

Alterations in intra- and inter-network connectivity associated with cognition impairment in insulinoma patients
por: Nong, Hui, et al.
Publicado: (2023)

The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis
por: Yang, Qin, et al.
Publicado: (2020)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells
por: Kong, Xiaohui, et al.
Publicado: (2022)

LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation
por: Gao, Haibing, et al.
Publicado: (2022)

lncRNA NEAT1/miR‐495‐3p regulates angiogenesis in burn sepsis through the TGF‐β1 and SMAD signaling pathways
por: Meng, Yanbin, et al.
Publicado: (2023)

LncRNA FAM83H-AS1 promotes the malignant progression of pancreatic ductal adenocarcinoma by stabilizing FAM83H mRNA to protect β-catenin from degradation
por: Zhou, Min, et al.
Publicado: (2022)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Identification of lncRNA FAM83H-AS1 as a novel prognostic marker in luminal subtype breast cancer
por: Yang, Fan, et al.
Publicado: (2016)

LncRNA FAM66C inhibits pancreatic cancer progression by sponging miR-574-3p
por: Zhu, Jiangang, et al.
Publicado: (2020)

Qingjie Fuzheng Granule Inhibited the Migration and Invasion of Colorectal Cancer Cells by Regulating the lncRNA ANRIL/let-7a/TGF-β1/Smad Axis
por: Zhang, Ling, et al.
Publicado: (2020)

Correction to ‘LncRNA-Smad7 mediates cross-talk between nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells’
Publicado: (2023)

The regulatory effect and molecular mechanism of lncRNA Gm10451 on islet cell dysfunction in children with diabetes
por: Wang, Jiao, et al.
Publicado: (2022)

Smad4-mediated TGF-β signaling in tumorigenesis
por: Yang, Guan, et al.
Publicado: (2010)

The regulation of TGF-β/SMAD signaling by protein deubiquitination
por: Zhang, Juan, et al.
Publicado: (2014)

The role of TGF-β/SMAD4 signaling in cancer
por: Zhao, Ming, et al.
Publicado: (2018)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells
por: Kunzmann, Steffen, et al.
Publicado: (2018)

Ablation of Fam20c causes amelogenesis imperfecta via inhibiting Smad dependent BMP signaling pathway
por: Liu, Jing, et al.
Publicado: (2020)

Endobronchial ultrasound-guided transbronchial needle aspiration combined with either endoscopic ultrasound-guided fine-needle aspiration or endoscopic ultrasound using the EBUS scope-guided fine-needle aspiration for diagnosing and staging mediastinal diseases: a systematic review and meta-analysis
por: Shen, Yanhua, et al.
Publicado: (2020)

Resveratrol Inhibits High Glucose-Induced H9c2 Cardiomyocyte Hypertrophy and Damage via RAGE-Dependent Inhibition of the NF-κB and TGF-β1/Smad3 Pathways
por: Zhu, Yanzhou, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9es8b8cnk1eefd1v8du9icveue