The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer

Thyroid cancer (TC) is the most predominant malignancy of the endocrine system, with steadily growing occurrence and morbidity worldwide. Although diagnostic and therapeutic methods have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of TC remain enig...

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Autores principales: Xu, Xiaoxin, Zhao, Jiayao, Yang, Mingyue, Han, Lutuo, Yuan, Xingxing, Chi, Wencheng, Jiang, Jiakang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621220/
https://www.ncbi.nlm.nih.gov/pubmed/37915103
http://dx.doi.org/10.1186/s40001-023-01382-2
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author Xu, Xiaoxin
Zhao, Jiayao
Yang, Mingyue
Han, Lutuo
Yuan, Xingxing
Chi, Wencheng
Jiang, Jiakang
author_facet Xu, Xiaoxin
Zhao, Jiayao
Yang, Mingyue
Han, Lutuo
Yuan, Xingxing
Chi, Wencheng
Jiang, Jiakang
author_sort Xu, Xiaoxin
collection PubMed
description Thyroid cancer (TC) is the most predominant malignancy of the endocrine system, with steadily growing occurrence and morbidity worldwide. Although diagnostic and therapeutic methods have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of TC remain enigmatic. The N6-methyladenosine(m6A) RNA modification is designed to impact RNA metabolism and further gene regulation. This process is intricately regulated by a variety of regulators, such as methylases and demethylases. Aberrant m6A regulators expression is related to the occurrence and development of TC and play an important role in drug resistance. This review comprehensively analyzes the effect of m6A methylation on TC progression and the potential clinical value of m6A regulators as prognostic markers and therapeutic targets in this disease.
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spelling pubmed-106212202023-11-03 The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer Xu, Xiaoxin Zhao, Jiayao Yang, Mingyue Han, Lutuo Yuan, Xingxing Chi, Wencheng Jiang, Jiakang Eur J Med Res Review Thyroid cancer (TC) is the most predominant malignancy of the endocrine system, with steadily growing occurrence and morbidity worldwide. Although diagnostic and therapeutic methods have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of TC remain enigmatic. The N6-methyladenosine(m6A) RNA modification is designed to impact RNA metabolism and further gene regulation. This process is intricately regulated by a variety of regulators, such as methylases and demethylases. Aberrant m6A regulators expression is related to the occurrence and development of TC and play an important role in drug resistance. This review comprehensively analyzes the effect of m6A methylation on TC progression and the potential clinical value of m6A regulators as prognostic markers and therapeutic targets in this disease. BioMed Central 2023-11-01 /pmc/articles/PMC10621220/ /pubmed/37915103 http://dx.doi.org/10.1186/s40001-023-01382-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xu, Xiaoxin
Zhao, Jiayao
Yang, Mingyue
Han, Lutuo
Yuan, Xingxing
Chi, Wencheng
Jiang, Jiakang
The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer
title The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer
title_full The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer
title_fullStr The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer
title_full_unstemmed The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer
title_short The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer
title_sort emerging roles of n6-methyladenosine rna modifications in thyroid cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621220/
https://www.ncbi.nlm.nih.gov/pubmed/37915103
http://dx.doi.org/10.1186/s40001-023-01382-2
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