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Intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat
CASE SUMMARY: A 9-year-old neutered female domestic shorthair cat was presented for investigation of a cranial mediastinal mass. Moderate peripheral eosinophilia and mild-to-moderate polyclonal gammopathy were identified. A thoracoabdominal CT scan documented a cranial mediastinal mass encircling th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621301/ https://www.ncbi.nlm.nih.gov/pubmed/37927535 http://dx.doi.org/10.1177/20551169231199447 |
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author | Duclos, Antoine A Wolfe, Alan Mooney, Carmel T |
author_facet | Duclos, Antoine A Wolfe, Alan Mooney, Carmel T |
author_sort | Duclos, Antoine A |
collection | PubMed |
description | CASE SUMMARY: A 9-year-old neutered female domestic shorthair cat was presented for investigation of a cranial mediastinal mass. Moderate peripheral eosinophilia and mild-to-moderate polyclonal gammopathy were identified. A thoracoabdominal CT scan documented a cranial mediastinal mass encircling the trachea. Ultrasound-guided fine-needle aspiration and core-needle biopsy were performed, but cytology and histopathology were inconclusive. Surgical debulking was performed. Further histological samples identified severe pyogranulomatous and eosinophilic fibrosing mediastinitis, consistent with feline eosinophilic sclerosing fibroplasia. Gram staining and fluorescence in situ hybridisation (FISH) identified numerous Gram-positive coccoid bacteria. Eosinophilia and hyperglobulinaemia resolved after surgery and combined antimicrobial and immunosuppressive therapy. The cat died 3 months later after developing acute haemorrhagic diarrhoea and dyspnoea. RELEVANCE AND NOVEL INFORMATION: Eosinophilic sclerosing fibroplasia is reportedly mainly confined to the gastrointestinal tract in cats. Less commonly, extragastrointestinal cases have been described. Lesions in the mediastinal or sternal lymph nodes have been reported, all in association with evident gastrointestinal involvement. The presence of pleural effusion was variable in these cases. To the authors’ knowledge, this is the first report of eosinophilic sclerosing fibroplasia presenting due to lower respiratory signs in a cat. Intralesional bacteria were identified using Gram staining and FISH examination. The presence of intralesional bacteria in the normally sterile mediastinal tissue may support the involvement of penetrating injuries in the pathogenesis of the disease. Eosinophilic sclerosing fibroplasia should be suspected in any cat with abdominal and/or thoracic masses, particularly if associated with peripheral eosinophilia and polyclonal gammopathy. |
format | Online Article Text |
id | pubmed-10621301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-106213012023-11-03 Intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat Duclos, Antoine A Wolfe, Alan Mooney, Carmel T JFMS Open Rep Case Report CASE SUMMARY: A 9-year-old neutered female domestic shorthair cat was presented for investigation of a cranial mediastinal mass. Moderate peripheral eosinophilia and mild-to-moderate polyclonal gammopathy were identified. A thoracoabdominal CT scan documented a cranial mediastinal mass encircling the trachea. Ultrasound-guided fine-needle aspiration and core-needle biopsy were performed, but cytology and histopathology were inconclusive. Surgical debulking was performed. Further histological samples identified severe pyogranulomatous and eosinophilic fibrosing mediastinitis, consistent with feline eosinophilic sclerosing fibroplasia. Gram staining and fluorescence in situ hybridisation (FISH) identified numerous Gram-positive coccoid bacteria. Eosinophilia and hyperglobulinaemia resolved after surgery and combined antimicrobial and immunosuppressive therapy. The cat died 3 months later after developing acute haemorrhagic diarrhoea and dyspnoea. RELEVANCE AND NOVEL INFORMATION: Eosinophilic sclerosing fibroplasia is reportedly mainly confined to the gastrointestinal tract in cats. Less commonly, extragastrointestinal cases have been described. Lesions in the mediastinal or sternal lymph nodes have been reported, all in association with evident gastrointestinal involvement. The presence of pleural effusion was variable in these cases. To the authors’ knowledge, this is the first report of eosinophilic sclerosing fibroplasia presenting due to lower respiratory signs in a cat. Intralesional bacteria were identified using Gram staining and FISH examination. The presence of intralesional bacteria in the normally sterile mediastinal tissue may support the involvement of penetrating injuries in the pathogenesis of the disease. Eosinophilic sclerosing fibroplasia should be suspected in any cat with abdominal and/or thoracic masses, particularly if associated with peripheral eosinophilia and polyclonal gammopathy. SAGE Publications 2023-11-01 /pmc/articles/PMC10621301/ /pubmed/37927535 http://dx.doi.org/10.1177/20551169231199447 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Duclos, Antoine A Wolfe, Alan Mooney, Carmel T Intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat |
title | Intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat |
title_full | Intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat |
title_fullStr | Intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat |
title_full_unstemmed | Intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat |
title_short | Intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat |
title_sort | intrathoracic eosinophilic sclerosing fibroplasia with intralesional bacteria in a cat |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621301/ https://www.ncbi.nlm.nih.gov/pubmed/37927535 http://dx.doi.org/10.1177/20551169231199447 |
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