NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors

Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society. Neuroinflammation is one of the main factors leading to cognitive impairment. The inflammasomes are multi-protein complexes that respond to various microorganisms and...

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Autores principales: Xu, Yi, Yang, Yanling, Chen, Xi, Jiang, Danling, Zhang, Fei, Guo, Yao, Hu, Bin, Xu, Guohai, Peng, Shengliang, Wu, Lidong, Hu, Jialing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621314/
https://www.ncbi.nlm.nih.gov/pubmed/37915104
http://dx.doi.org/10.1186/s40035-023-00381-x
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author Xu, Yi
Yang, Yanling
Chen, Xi
Jiang, Danling
Zhang, Fei
Guo, Yao
Hu, Bin
Xu, Guohai
Peng, Shengliang
Wu, Lidong
Hu, Jialing
author_facet Xu, Yi
Yang, Yanling
Chen, Xi
Jiang, Danling
Zhang, Fei
Guo, Yao
Hu, Bin
Xu, Guohai
Peng, Shengliang
Wu, Lidong
Hu, Jialing
author_sort Xu, Yi
collection PubMed
description Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society. Neuroinflammation is one of the main factors leading to cognitive impairment. The inflammasomes are multi-protein complexes that respond to various microorganisms and endogenous danger signals, helping to initiate innate protective responses in inflammatory diseases. NLRP3 inflammasomes produce proinflammatory cytokines (interleukin IL-1β and IL-18) by activating caspase-1. In this review, we comprehensively describe the structure and functions of the NLRP3 inflammasome. We also explore the intrinsic relationship between the NLRP3 inflammasome and cognitive impairment, which involves immune cell activation, cell apoptosis, oxidative stress, mitochondrial autophagy, and neuroinflammation. Finally, we describe NLRP3 inflammasome antagonists as targeted therapies to improve cognitive impairment.
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spelling pubmed-106213142023-11-03 NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors Xu, Yi Yang, Yanling Chen, Xi Jiang, Danling Zhang, Fei Guo, Yao Hu, Bin Xu, Guohai Peng, Shengliang Wu, Lidong Hu, Jialing Transl Neurodegener Review Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society. Neuroinflammation is one of the main factors leading to cognitive impairment. The inflammasomes are multi-protein complexes that respond to various microorganisms and endogenous danger signals, helping to initiate innate protective responses in inflammatory diseases. NLRP3 inflammasomes produce proinflammatory cytokines (interleukin IL-1β and IL-18) by activating caspase-1. In this review, we comprehensively describe the structure and functions of the NLRP3 inflammasome. We also explore the intrinsic relationship between the NLRP3 inflammasome and cognitive impairment, which involves immune cell activation, cell apoptosis, oxidative stress, mitochondrial autophagy, and neuroinflammation. Finally, we describe NLRP3 inflammasome antagonists as targeted therapies to improve cognitive impairment. BioMed Central 2023-11-02 /pmc/articles/PMC10621314/ /pubmed/37915104 http://dx.doi.org/10.1186/s40035-023-00381-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xu, Yi
Yang, Yanling
Chen, Xi
Jiang, Danling
Zhang, Fei
Guo, Yao
Hu, Bin
Xu, Guohai
Peng, Shengliang
Wu, Lidong
Hu, Jialing
NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
title NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
title_full NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
title_fullStr NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
title_full_unstemmed NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
title_short NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
title_sort nlrp3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621314/
https://www.ncbi.nlm.nih.gov/pubmed/37915104
http://dx.doi.org/10.1186/s40035-023-00381-x
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