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Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation

Neural tube defect is a congenital anomaly resulting from the failure of fusion of the neural folds in the midline which occurs in the third and the fourth week of embryonic development. These defects can occur at any of the three embryological stages—gastrulation, primary neurulation and secondary...

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Autores principales: Sinha, Pallavi, Kumar, Atin, Jana, Manisha, Kandasamy, Devasenathipathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621580/
https://www.ncbi.nlm.nih.gov/pubmed/37928696
http://dx.doi.org/10.1259/bjrcr.20230005
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author Sinha, Pallavi
Kumar, Atin
Jana, Manisha
Kandasamy, Devasenathipathy
author_facet Sinha, Pallavi
Kumar, Atin
Jana, Manisha
Kandasamy, Devasenathipathy
author_sort Sinha, Pallavi
collection PubMed
description Neural tube defect is a congenital anomaly resulting from the failure of fusion of the neural folds in the midline which occurs in the third and the fourth week of embryonic development. These defects can occur at any of the three embryological stages—gastrulation, primary neurulation and secondary neurulation. Presence of neural tube defects at multiple (two or more) sites along the craniospinal axis is an extremely rare anomaly and the management depends on clinical as well as imaging findings. These multiple defects are not well explained by the “Zipper closure” theory and can be better explained by the “Multisite closure theory”, which will be highlighted in this manuscript. Few of these multiple site anomalies cannot be fully explained even by the multisite closure theory and more research is needed to decipher this entity.
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spelling pubmed-106215802023-11-03 Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation Sinha, Pallavi Kumar, Atin Jana, Manisha Kandasamy, Devasenathipathy BJR Case Rep Case Report Neural tube defect is a congenital anomaly resulting from the failure of fusion of the neural folds in the midline which occurs in the third and the fourth week of embryonic development. These defects can occur at any of the three embryological stages—gastrulation, primary neurulation and secondary neurulation. Presence of neural tube defects at multiple (two or more) sites along the craniospinal axis is an extremely rare anomaly and the management depends on clinical as well as imaging findings. These multiple defects are not well explained by the “Zipper closure” theory and can be better explained by the “Multisite closure theory”, which will be highlighted in this manuscript. Few of these multiple site anomalies cannot be fully explained even by the multisite closure theory and more research is needed to decipher this entity. The British Institute of Radiology. 2023-07-10 /pmc/articles/PMC10621580/ /pubmed/37928696 http://dx.doi.org/10.1259/bjrcr.20230005 Text en © 2023 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Sinha, Pallavi
Kumar, Atin
Jana, Manisha
Kandasamy, Devasenathipathy
Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation
title Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation
title_full Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation
title_fullStr Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation
title_full_unstemmed Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation
title_short Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation
title_sort multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621580/
https://www.ncbi.nlm.nih.gov/pubmed/37928696
http://dx.doi.org/10.1259/bjrcr.20230005
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