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Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward

Turnera aphrodisiaca Ward (Turneraceae) has been traditionally used for the treatment of anxiety neurosis, and as an aphrodisiac. Mother tinctures (85% ethanol extracts) of T. aphrodisiaca have also been used for the treatment of central nervous system disorders. In the present investigation, T. aph...

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Detalles Bibliográficos
Autores principales: Kumar, Suresh, Sharma, Anupam
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1062162/
https://www.ncbi.nlm.nih.gov/pubmed/15864356
http://dx.doi.org/10.1093/ecam/neh069
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author Kumar, Suresh
Sharma, Anupam
author_facet Kumar, Suresh
Sharma, Anupam
author_sort Kumar, Suresh
collection PubMed
description Turnera aphrodisiaca Ward (Turneraceae) has been traditionally used for the treatment of anxiety neurosis, and as an aphrodisiac. Mother tinctures (85% ethanol extracts) of T. aphrodisiaca have also been used for the treatment of central nervous system disorders. In the present investigation, T. aphrodisiaca mother tinctures formulated by three reputed manufacturers of homoeopathic medicines (NLK, DWSG and SBL) were evaluated for their anxiolytic activity. Dried mother tinctures of T. aphrodisiaca were subjected to anxiolytic activity evaluation at various doses, i.e. 50, 75, 100, 125 or 150 mg/kg p.o. in mice using elevated plus maze apparatus. Dried mother tinctures exhibited significant anxiolytic activity at 50 mg/kg (NLK), 75 mg/kg (DWSG) and 125 mg/kg (SBL), respectively, with reference to control as well as standard (diazepam, 2 mg/kg p.o.). Mother tinctures of T. aphrodisiaca available in the market, have significant anxiolytic activity. Amongst the three mother tinctures of T. aphrodisiaca analyzed, the dry residue of NLK possesses the highest amount of anxiolytic constituent(s). To ensure uniformity and consistency of biological effects in herbal formulations, these should be standardized on the basis of bioactive markers. The authors are actively involved in isolating the bioactive constituent(s) from T. aphrodisiaca so that the plant can be standardized on the basis of biologically active constituent(s).
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spelling pubmed-10621622005-04-29 Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward Kumar, Suresh Sharma, Anupam Evid Based Complement Alternat Med Brief Communication Turnera aphrodisiaca Ward (Turneraceae) has been traditionally used for the treatment of anxiety neurosis, and as an aphrodisiac. Mother tinctures (85% ethanol extracts) of T. aphrodisiaca have also been used for the treatment of central nervous system disorders. In the present investigation, T. aphrodisiaca mother tinctures formulated by three reputed manufacturers of homoeopathic medicines (NLK, DWSG and SBL) were evaluated for their anxiolytic activity. Dried mother tinctures of T. aphrodisiaca were subjected to anxiolytic activity evaluation at various doses, i.e. 50, 75, 100, 125 or 150 mg/kg p.o. in mice using elevated plus maze apparatus. Dried mother tinctures exhibited significant anxiolytic activity at 50 mg/kg (NLK), 75 mg/kg (DWSG) and 125 mg/kg (SBL), respectively, with reference to control as well as standard (diazepam, 2 mg/kg p.o.). Mother tinctures of T. aphrodisiaca available in the market, have significant anxiolytic activity. Amongst the three mother tinctures of T. aphrodisiaca analyzed, the dry residue of NLK possesses the highest amount of anxiolytic constituent(s). To ensure uniformity and consistency of biological effects in herbal formulations, these should be standardized on the basis of bioactive markers. The authors are actively involved in isolating the bioactive constituent(s) from T. aphrodisiaca so that the plant can be standardized on the basis of biologically active constituent(s). Oxford University Press 2005-03 2005-02-09 /pmc/articles/PMC1062162/ /pubmed/15864356 http://dx.doi.org/10.1093/ecam/neh069 Text en © The Author (2005). Published by Oxford University Press. All rights reserved.
spellingShingle Brief Communication
Kumar, Suresh
Sharma, Anupam
Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward
title Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward
title_full Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward
title_fullStr Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward
title_full_unstemmed Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward
title_short Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward
title_sort anti-anxiety activity studies on homoeopathic formulations of turnera aphrodisiaca ward
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1062162/
https://www.ncbi.nlm.nih.gov/pubmed/15864356
http://dx.doi.org/10.1093/ecam/neh069
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