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Mechanisms and effects of metformin on skeletal muscle disorders

Skeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically...

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Autores principales: Shang, Ren, Miao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621799/
https://www.ncbi.nlm.nih.gov/pubmed/37928155
http://dx.doi.org/10.3389/fneur.2023.1275266
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author Shang, Ren
Miao, Jing
author_facet Shang, Ren
Miao, Jing
author_sort Shang, Ren
collection PubMed
description Skeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically, hence the development of novel treatments for neuromuscular diseases is crucial to obtain a better quality of life. As a widely used hypoglycemic drug in clinical practice, metformin not only has anti-inflammatory, autophagy-regulating, and mitochondrial biogenesis-regulating effects, but it has also been reported to improve the symptoms of neuromuscular diseases, delay hypokinesia, and regulate skeletal muscle mass. However, metformin’s specific mechanism of action in neuromuscular diseases requires further elucidation. This review summarizes the evidence showing that metformin can regulate inflammation, autophagy, and mitochondrial biogenesis through different pathways, and further explores its mechanism of action in Duchenne muscular dystrophy, statin-associated muscle disorders, and age-related sarcopenia. This review clarifies the directions of future research on therapy for neuromuscular diseases.
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spelling pubmed-106217992023-11-03 Mechanisms and effects of metformin on skeletal muscle disorders Shang, Ren Miao, Jing Front Neurol Neurology Skeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically, hence the development of novel treatments for neuromuscular diseases is crucial to obtain a better quality of life. As a widely used hypoglycemic drug in clinical practice, metformin not only has anti-inflammatory, autophagy-regulating, and mitochondrial biogenesis-regulating effects, but it has also been reported to improve the symptoms of neuromuscular diseases, delay hypokinesia, and regulate skeletal muscle mass. However, metformin’s specific mechanism of action in neuromuscular diseases requires further elucidation. This review summarizes the evidence showing that metformin can regulate inflammation, autophagy, and mitochondrial biogenesis through different pathways, and further explores its mechanism of action in Duchenne muscular dystrophy, statin-associated muscle disorders, and age-related sarcopenia. This review clarifies the directions of future research on therapy for neuromuscular diseases. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10621799/ /pubmed/37928155 http://dx.doi.org/10.3389/fneur.2023.1275266 Text en Copyright © 2023 Shang and Miao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Shang, Ren
Miao, Jing
Mechanisms and effects of metformin on skeletal muscle disorders
title Mechanisms and effects of metformin on skeletal muscle disorders
title_full Mechanisms and effects of metformin on skeletal muscle disorders
title_fullStr Mechanisms and effects of metformin on skeletal muscle disorders
title_full_unstemmed Mechanisms and effects of metformin on skeletal muscle disorders
title_short Mechanisms and effects of metformin on skeletal muscle disorders
title_sort mechanisms and effects of metformin on skeletal muscle disorders
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621799/
https://www.ncbi.nlm.nih.gov/pubmed/37928155
http://dx.doi.org/10.3389/fneur.2023.1275266
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