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Mechanisms and effects of metformin on skeletal muscle disorders
Skeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621799/ https://www.ncbi.nlm.nih.gov/pubmed/37928155 http://dx.doi.org/10.3389/fneur.2023.1275266 |
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author | Shang, Ren Miao, Jing |
author_facet | Shang, Ren Miao, Jing |
author_sort | Shang, Ren |
collection | PubMed |
description | Skeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically, hence the development of novel treatments for neuromuscular diseases is crucial to obtain a better quality of life. As a widely used hypoglycemic drug in clinical practice, metformin not only has anti-inflammatory, autophagy-regulating, and mitochondrial biogenesis-regulating effects, but it has also been reported to improve the symptoms of neuromuscular diseases, delay hypokinesia, and regulate skeletal muscle mass. However, metformin’s specific mechanism of action in neuromuscular diseases requires further elucidation. This review summarizes the evidence showing that metformin can regulate inflammation, autophagy, and mitochondrial biogenesis through different pathways, and further explores its mechanism of action in Duchenne muscular dystrophy, statin-associated muscle disorders, and age-related sarcopenia. This review clarifies the directions of future research on therapy for neuromuscular diseases. |
format | Online Article Text |
id | pubmed-10621799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106217992023-11-03 Mechanisms and effects of metformin on skeletal muscle disorders Shang, Ren Miao, Jing Front Neurol Neurology Skeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically, hence the development of novel treatments for neuromuscular diseases is crucial to obtain a better quality of life. As a widely used hypoglycemic drug in clinical practice, metformin not only has anti-inflammatory, autophagy-regulating, and mitochondrial biogenesis-regulating effects, but it has also been reported to improve the symptoms of neuromuscular diseases, delay hypokinesia, and regulate skeletal muscle mass. However, metformin’s specific mechanism of action in neuromuscular diseases requires further elucidation. This review summarizes the evidence showing that metformin can regulate inflammation, autophagy, and mitochondrial biogenesis through different pathways, and further explores its mechanism of action in Duchenne muscular dystrophy, statin-associated muscle disorders, and age-related sarcopenia. This review clarifies the directions of future research on therapy for neuromuscular diseases. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10621799/ /pubmed/37928155 http://dx.doi.org/10.3389/fneur.2023.1275266 Text en Copyright © 2023 Shang and Miao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Shang, Ren Miao, Jing Mechanisms and effects of metformin on skeletal muscle disorders |
title | Mechanisms and effects of metformin on skeletal muscle disorders |
title_full | Mechanisms and effects of metformin on skeletal muscle disorders |
title_fullStr | Mechanisms and effects of metformin on skeletal muscle disorders |
title_full_unstemmed | Mechanisms and effects of metformin on skeletal muscle disorders |
title_short | Mechanisms and effects of metformin on skeletal muscle disorders |
title_sort | mechanisms and effects of metformin on skeletal muscle disorders |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621799/ https://www.ncbi.nlm.nih.gov/pubmed/37928155 http://dx.doi.org/10.3389/fneur.2023.1275266 |
work_keys_str_mv | AT shangren mechanismsandeffectsofmetforminonskeletalmuscledisorders AT miaojing mechanismsandeffectsofmetforminonskeletalmuscledisorders |