Cargando…
iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons
Motor neuron degeneration, the defining feature of amyotrophic lateral sclerosis (ALS), is a primary example of cell-type specificity in neurodegenerative diseases. Using isogenic pairs of induced pluripotent stem cells (iPSCs) harboring different familial ALS mutations, we assess the capacity of iP...
Autores principales: | Held, Aaron, Adler, Michelle, Marques, Christine, Reyes, Charles Jourdan, Kavuturu, Amey S., Quadros, Ana R.A.A., Ndayambaje, I. Sandra, Lara, Erika, Ward, Michael, Lagier-Tourenne, Clotilde, Wainger, Brian J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622181/ https://www.ncbi.nlm.nih.gov/pubmed/37651231 http://dx.doi.org/10.1016/j.celrep.2023.113046 |
Ejemplares similares
-
Decay in survival motor neuron and plastin 3 levels during differentiation of iPSC-derived human motor neurons
por: Boza-Morán, María G, et al.
Publicado: (2015) -
Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons
por: Allison, Reilly L., et al.
Publicado: (2022) -
Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation
por: Solomon, Emilia, et al.
Publicado: (2021) -
An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids
por: Castellanos-Montiel, María José, et al.
Publicado: (2023) -
Modeling Protein Aggregation and the Heat Shock Response in ALS iPSC-Derived Motor Neurons
por: Seminary, Emily R., et al.
Publicado: (2018)