iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons

Motor neuron degeneration, the defining feature of amyotrophic lateral sclerosis (ALS), is a primary example of cell-type specificity in neurodegenerative diseases. Using isogenic pairs of induced pluripotent stem cells (iPSCs) harboring different familial ALS mutations, we assess the capacity of iP...

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Detalles Bibliográficos
Autores principales: Held, Aaron, Adler, Michelle, Marques, Christine, Reyes, Charles Jourdan, Kavuturu, Amey S., Quadros, Ana R.A.A., Ndayambaje, I. Sandra, Lara, Erika, Ward, Michael, Lagier-Tourenne, Clotilde, Wainger, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622181/
https://www.ncbi.nlm.nih.gov/pubmed/37651231
http://dx.doi.org/10.1016/j.celrep.2023.113046

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