Complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib

INTRODUCTION: The effectiveness of nivolumab plus cabozantinib for metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus remains unclear. CASE PRESENTATION: A 77‐year‐old male was diagnosed with right papillary renal cell carcinoma with a metastatic lesion on Gerota's...

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Autores principales: Hayashida, Michikata, Miura, Yuji, Yamaguchi, Takeshi, Tanaka, Makoto, Yamanaka, Taro, Takemura, Kohji, Oka, Suguru, Sakaguchi, Kazushige, Ito, Shinji, Urakami, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622194/
https://www.ncbi.nlm.nih.gov/pubmed/37928303
http://dx.doi.org/10.1002/iju5.12638
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author Hayashida, Michikata
Miura, Yuji
Yamaguchi, Takeshi
Tanaka, Makoto
Yamanaka, Taro
Takemura, Kohji
Oka, Suguru
Sakaguchi, Kazushige
Ito, Shinji
Urakami, Shinji
author_facet Hayashida, Michikata
Miura, Yuji
Yamaguchi, Takeshi
Tanaka, Makoto
Yamanaka, Taro
Takemura, Kohji
Oka, Suguru
Sakaguchi, Kazushige
Ito, Shinji
Urakami, Shinji
author_sort Hayashida, Michikata
collection PubMed
description INTRODUCTION: The effectiveness of nivolumab plus cabozantinib for metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus remains unclear. CASE PRESENTATION: A 77‐year‐old male was diagnosed with right papillary renal cell carcinoma with a metastatic lesion on Gerota's fascia, lymph node metastasis, and inferior vena cava tumor thrombus. He was treated with nivolumab plus cabozantinib. As all lesions regressed enough to permit complete resection, radical nephrectomy, thrombectomy, and retroperitoneal lymph node dissection were performed. No viable malignant cells were identified histopathologically. Despite the discontinuation of nivolumab plus cabozantinib, there has been no recurrence for 9 months. CONCLUSION: Nivolumab plus cabozantinib has effectiveness for metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus.
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spelling pubmed-106221942023-11-03 Complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib Hayashida, Michikata Miura, Yuji Yamaguchi, Takeshi Tanaka, Makoto Yamanaka, Taro Takemura, Kohji Oka, Suguru Sakaguchi, Kazushige Ito, Shinji Urakami, Shinji IJU Case Rep Case Reports INTRODUCTION: The effectiveness of nivolumab plus cabozantinib for metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus remains unclear. CASE PRESENTATION: A 77‐year‐old male was diagnosed with right papillary renal cell carcinoma with a metastatic lesion on Gerota's fascia, lymph node metastasis, and inferior vena cava tumor thrombus. He was treated with nivolumab plus cabozantinib. As all lesions regressed enough to permit complete resection, radical nephrectomy, thrombectomy, and retroperitoneal lymph node dissection were performed. No viable malignant cells were identified histopathologically. Despite the discontinuation of nivolumab plus cabozantinib, there has been no recurrence for 9 months. CONCLUSION: Nivolumab plus cabozantinib has effectiveness for metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus. John Wiley and Sons Inc. 2023-09-05 /pmc/articles/PMC10622194/ /pubmed/37928303 http://dx.doi.org/10.1002/iju5.12638 Text en © 2023 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Hayashida, Michikata
Miura, Yuji
Yamaguchi, Takeshi
Tanaka, Makoto
Yamanaka, Taro
Takemura, Kohji
Oka, Suguru
Sakaguchi, Kazushige
Ito, Shinji
Urakami, Shinji
Complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib
title Complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib
title_full Complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib
title_fullStr Complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib
title_full_unstemmed Complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib
title_short Complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib
title_sort complete response of metastatic papillary renal cell carcinoma with inferior vena cava tumor thrombus to nivolumab plus cabozantinib
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622194/
https://www.ncbi.nlm.nih.gov/pubmed/37928303
http://dx.doi.org/10.1002/iju5.12638
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