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Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia
Chronic traumatic encephalopathy (CTE) is a neuropathological diagnosis defined by a unique pattern of hyperphosphorylated tau (p-tau) accumulation that begins in neocortical regions of the brain. It is associated with a range of neuropsychological symptoms, but a definitive diagnosis can only be ma...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622321/ https://www.ncbi.nlm.nih.gov/pubmed/35947764 http://dx.doi.org/10.1093/jnen/nlac071 |
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author | Suter, Catherine M Affleck, Andrew J Lee, Maggie Davies, Danielle Burns, Arran L Sy, Joanne I’Ons, Bernard Buckland, Michael E |
author_facet | Suter, Catherine M Affleck, Andrew J Lee, Maggie Davies, Danielle Burns, Arran L Sy, Joanne I’Ons, Bernard Buckland, Michael E |
author_sort | Suter, Catherine M |
collection | PubMed |
description | Chronic traumatic encephalopathy (CTE) is a neuropathological diagnosis defined by a unique pattern of hyperphosphorylated tau (p-tau) accumulation that begins in neocortical regions of the brain. It is associated with a range of neuropsychological symptoms, but a definitive diagnosis can only be made by postmortem brain examination. In 2018, we instituted CTE screening for all autopsy brains as part of our routine departmental protocol by performing p-tau immunohistochemistry on a restricted set of 3 neocortical blocks (frontal, temporal, and parietal). This strategy allowed us to identify 4 cases of low-stage CTE from 180 consecutive autopsies. Two of the 4 cases had a documented history of brain injury; for the remaining 2 cases, there was a long history of treatment-resistant tonic/clonic epilepsy suggesting that undocumented brain injuries may have occurred. Our experience indicates that 3-block CTE screening is useful in identifying CTE in routine practice. The results of this study further support the association between prior head injuries and CTE and demonstrate that, albeit uncommon, CTE does occur in the general population. Our findings suggest that p-tau screening should be routinely pursued in brain autopsy, particularly where there is a documented or likely history of traumatic brain injury. |
format | Online Article Text |
id | pubmed-10622321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106223212023-11-04 Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia Suter, Catherine M Affleck, Andrew J Lee, Maggie Davies, Danielle Burns, Arran L Sy, Joanne I’Ons, Bernard Buckland, Michael E J Neuropathol Exp Neurol Original Articles Chronic traumatic encephalopathy (CTE) is a neuropathological diagnosis defined by a unique pattern of hyperphosphorylated tau (p-tau) accumulation that begins in neocortical regions of the brain. It is associated with a range of neuropsychological symptoms, but a definitive diagnosis can only be made by postmortem brain examination. In 2018, we instituted CTE screening for all autopsy brains as part of our routine departmental protocol by performing p-tau immunohistochemistry on a restricted set of 3 neocortical blocks (frontal, temporal, and parietal). This strategy allowed us to identify 4 cases of low-stage CTE from 180 consecutive autopsies. Two of the 4 cases had a documented history of brain injury; for the remaining 2 cases, there was a long history of treatment-resistant tonic/clonic epilepsy suggesting that undocumented brain injuries may have occurred. Our experience indicates that 3-block CTE screening is useful in identifying CTE in routine practice. The results of this study further support the association between prior head injuries and CTE and demonstrate that, albeit uncommon, CTE does occur in the general population. Our findings suggest that p-tau screening should be routinely pursued in brain autopsy, particularly where there is a documented or likely history of traumatic brain injury. Oxford University Press 2022-08-10 /pmc/articles/PMC10622321/ /pubmed/35947764 http://dx.doi.org/10.1093/jnen/nlac071 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of American Association of Neuropathologists, Inc. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Suter, Catherine M Affleck, Andrew J Lee, Maggie Davies, Danielle Burns, Arran L Sy, Joanne I’Ons, Bernard Buckland, Michael E Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia |
title | Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia |
title_full | Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia |
title_fullStr | Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia |
title_full_unstemmed | Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia |
title_short | Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia |
title_sort | chronic traumatic encephalopathy in a routine neuropathology service in australia |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622321/ https://www.ncbi.nlm.nih.gov/pubmed/35947764 http://dx.doi.org/10.1093/jnen/nlac071 |
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