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Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism

Inverted duplications, also known as foldback inversions, are commonly observed in cancers and are the major class of chromosome rearrangement recovered from yeast cells lacking Mre11 nuclease activity. Foldback priming at DNA double-strand breaks (DSBs) is one mechanism proposed for the generation...

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Detalles Bibliográficos
Autores principales:	Al-Zain, Amr M., Nester, Mattie R., Ahmed, Iffat, Symington, Lorraine S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622511/ https://www.ncbi.nlm.nih.gov/pubmed/37919272 http://dx.doi.org/10.1038/s41467-023-42640-5

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