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Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia
The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the gl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622657/ https://www.ncbi.nlm.nih.gov/pubmed/37928135 http://dx.doi.org/10.3389/fneur.2023.1254981 |
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author | Disserol, Caio César Diniz Kowacs, Dora Pedroso Nabhan, Samir Kanaan Teive, Hélio Afonso Ghizoni Kowacs, Pedro André |
author_facet | Disserol, Caio César Diniz Kowacs, Dora Pedroso Nabhan, Samir Kanaan Teive, Hélio Afonso Ghizoni Kowacs, Pedro André |
author_sort | Disserol, Caio César Diniz |
collection | PubMed |
description | The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease. |
format | Online Article Text |
id | pubmed-10622657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106226572023-11-04 Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia Disserol, Caio César Diniz Kowacs, Dora Pedroso Nabhan, Samir Kanaan Teive, Hélio Afonso Ghizoni Kowacs, Pedro André Front Neurol Neurology The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10622657/ /pubmed/37928135 http://dx.doi.org/10.3389/fneur.2023.1254981 Text en Copyright © 2023 Disserol, Kowacs, Nabhan, Teive and Kowacs. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Disserol, Caio César Diniz Kowacs, Dora Pedroso Nabhan, Samir Kanaan Teive, Hélio Afonso Ghizoni Kowacs, Pedro André Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
title | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
title_full | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
title_fullStr | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
title_full_unstemmed | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
title_short | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
title_sort | case report: successful autologous hematopoietic stem cell transplantation in a patient with gad antibody-spectrum disorder with rapidly progressive dementia |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622657/ https://www.ncbi.nlm.nih.gov/pubmed/37928135 http://dx.doi.org/10.3389/fneur.2023.1254981 |
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