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Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis

INTRODUCTION: Deep brain stimulation of the subthalamic nucleus (STN-DBS) can exert relevant effects on the voice of patients with Parkinson's disease (PD). In this study, we used artificial intelligence to objectively analyze the voices of PD patients with STN-DBS. MATERIALS AND METHODS: In a...

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Autores principales: Suppa, Antonio, Asci, Francesco, Costantini, Giovanni, Bove, Francesco, Piano, Carla, Pistoia, Francesca, Cerroni, Rocco, Brusa, Livia, Cesarini, Valerio, Pietracupa, Sara, Modugno, Nicola, Zampogna, Alessandro, Sucapane, Patrizia, Pierantozzi, Mariangela, Tufo, Tommaso, Pisani, Antonio, Peppe, Antonella, Stefani, Alessandro, Calabresi, Paolo, Bentivoglio, Anna Rita, Saggio, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622670/
https://www.ncbi.nlm.nih.gov/pubmed/37928137
http://dx.doi.org/10.3389/fneur.2023.1267360
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author Suppa, Antonio
Asci, Francesco
Costantini, Giovanni
Bove, Francesco
Piano, Carla
Pistoia, Francesca
Cerroni, Rocco
Brusa, Livia
Cesarini, Valerio
Pietracupa, Sara
Modugno, Nicola
Zampogna, Alessandro
Sucapane, Patrizia
Pierantozzi, Mariangela
Tufo, Tommaso
Pisani, Antonio
Peppe, Antonella
Stefani, Alessandro
Calabresi, Paolo
Bentivoglio, Anna Rita
Saggio, Giovanni
author_facet Suppa, Antonio
Asci, Francesco
Costantini, Giovanni
Bove, Francesco
Piano, Carla
Pistoia, Francesca
Cerroni, Rocco
Brusa, Livia
Cesarini, Valerio
Pietracupa, Sara
Modugno, Nicola
Zampogna, Alessandro
Sucapane, Patrizia
Pierantozzi, Mariangela
Tufo, Tommaso
Pisani, Antonio
Peppe, Antonella
Stefani, Alessandro
Calabresi, Paolo
Bentivoglio, Anna Rita
Saggio, Giovanni
author_sort Suppa, Antonio
collection PubMed
description INTRODUCTION: Deep brain stimulation of the subthalamic nucleus (STN-DBS) can exert relevant effects on the voice of patients with Parkinson's disease (PD). In this study, we used artificial intelligence to objectively analyze the voices of PD patients with STN-DBS. MATERIALS AND METHODS: In a cross-sectional study, we enrolled 108 controls and 101 patients with PD. The cohort of PD was divided into two groups: the first group included 50 patients with STN-DBS, and the second group included 51 patients receiving the best medical treatment. The voices were clinically evaluated using the Unified Parkinson's Disease Rating Scale part-III subitem for voice (UPDRS-III-v). We recorded and then analyzed voices using specific machine-learning algorithms. The likelihood ratio (LR) was also calculated as an objective measure for clinical-instrumental correlations. RESULTS: Clinically, voice impairment was greater in STN-DBS patients than in those who received oral treatment. Using machine learning, we objectively and accurately distinguished between the voices of STN-DBS patients and those under oral treatments. We also found significant clinical-instrumental correlations since the greater the LRs, the higher the UPDRS-III-v scores. DISCUSSION: STN-DBS deteriorates speech in patients with PD, as objectively demonstrated by machine-learning voice analysis.
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spelling pubmed-106226702023-11-04 Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis Suppa, Antonio Asci, Francesco Costantini, Giovanni Bove, Francesco Piano, Carla Pistoia, Francesca Cerroni, Rocco Brusa, Livia Cesarini, Valerio Pietracupa, Sara Modugno, Nicola Zampogna, Alessandro Sucapane, Patrizia Pierantozzi, Mariangela Tufo, Tommaso Pisani, Antonio Peppe, Antonella Stefani, Alessandro Calabresi, Paolo Bentivoglio, Anna Rita Saggio, Giovanni Front Neurol Neurology INTRODUCTION: Deep brain stimulation of the subthalamic nucleus (STN-DBS) can exert relevant effects on the voice of patients with Parkinson's disease (PD). In this study, we used artificial intelligence to objectively analyze the voices of PD patients with STN-DBS. MATERIALS AND METHODS: In a cross-sectional study, we enrolled 108 controls and 101 patients with PD. The cohort of PD was divided into two groups: the first group included 50 patients with STN-DBS, and the second group included 51 patients receiving the best medical treatment. The voices were clinically evaluated using the Unified Parkinson's Disease Rating Scale part-III subitem for voice (UPDRS-III-v). We recorded and then analyzed voices using specific machine-learning algorithms. The likelihood ratio (LR) was also calculated as an objective measure for clinical-instrumental correlations. RESULTS: Clinically, voice impairment was greater in STN-DBS patients than in those who received oral treatment. Using machine learning, we objectively and accurately distinguished between the voices of STN-DBS patients and those under oral treatments. We also found significant clinical-instrumental correlations since the greater the LRs, the higher the UPDRS-III-v scores. DISCUSSION: STN-DBS deteriorates speech in patients with PD, as objectively demonstrated by machine-learning voice analysis. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10622670/ /pubmed/37928137 http://dx.doi.org/10.3389/fneur.2023.1267360 Text en Copyright © 2023 Suppa, Asci, Costantini, Bove, Piano, Pistoia, Cerroni, Brusa, Cesarini, Pietracupa, Modugno, Zampogna, Sucapane, Pierantozzi, Tufo, Pisani, Peppe, Stefani, Calabresi, Bentivoglio, Saggio and Lazio DBS Study Group. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Suppa, Antonio
Asci, Francesco
Costantini, Giovanni
Bove, Francesco
Piano, Carla
Pistoia, Francesca
Cerroni, Rocco
Brusa, Livia
Cesarini, Valerio
Pietracupa, Sara
Modugno, Nicola
Zampogna, Alessandro
Sucapane, Patrizia
Pierantozzi, Mariangela
Tufo, Tommaso
Pisani, Antonio
Peppe, Antonella
Stefani, Alessandro
Calabresi, Paolo
Bentivoglio, Anna Rita
Saggio, Giovanni
Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
title Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
title_full Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
title_fullStr Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
title_full_unstemmed Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
title_short Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
title_sort effects of deep brain stimulation of the subthalamic nucleus on patients with parkinson's disease: a machine-learning voice analysis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622670/
https://www.ncbi.nlm.nih.gov/pubmed/37928137
http://dx.doi.org/10.3389/fneur.2023.1267360
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